Talwar P, Kumar B, Ayyagiri A, Kaur S
Sabouraudia. 1985 Aug;23(4):303-12. doi: 10.1080/00362178585380431.
Ninety-six patients with clinical evidence of interdigital lesions classified as mild, moderate and severe athlete's foot were investigated for bacterial and fungal populations in the interspaces. Gram-negative bacteria, which were not found in the toe spaces of 50 normal controls, were grown in increasing numbers and with increasing frequency as the symptoms progressed from mild to severe. Gram-positive bacteria were also isolated regularly and in increasing numbers commensurate with the severity of the disease. Similarly the isolation rates of dermatophytes and Candida species were higher in patients with moderate and severe disease compared to those with mild disease. Clinical and culture responses to topical applications with framycetin, tolnaftate, miconazole and clotrimazole were also studied. In some patients the prevalence of pathogenic fungi increased as bacterial numbers decreased. The pure antibacterial framycetin brought symptomatic relief, as did the purely anti-dermatophyte substance tolnaftate, but best results were seen with two azole compounds having mixed antibacterial and antifungal properties.
对96例有趾间病变临床证据、被分类为轻度、中度和重度足癣的患者，研究其趾间的细菌和真菌菌群。革兰氏阴性菌在50例正常对照的趾间未被发现，随着症状从轻度发展到重度，其生长数量和频率不断增加。革兰氏阳性菌也经常被分离出来，且数量随着疾病严重程度的增加而增多。同样，与轻度疾病患者相比，中度和重度疾病患者皮肤癣菌和念珠菌属的分离率更高。还研究了外用硫酸新霉素、托萘酯、咪康唑和克霉唑后的临床和培养反应。在一些患者中，随着细菌数量减少，致病真菌的患病率增加。纯抗菌药硫酸新霉素能缓解症状，纯抗皮肤癣菌物质托萘酯也有同样效果，但具有抗菌和抗真菌双重特性的两种唑类化合物效果最佳。
