Nohr C W, Tchervenkov J I, Meakins J L, Christou N V
Surgery. 1985 Oct;98(4):769-76.
The effects of short-term acute nutritional deprivation and refeeding on immune function was investigated in rats. Animals previously sensitized to keyhole-limpet hemocyanin were starved for 72 hours and refed for 7 days. Recall skin testing with keyhole-limpet hemocyanin and immunization with tetanus toxoid (TT) were used to assess delayed-type hypersensitivity (DTH) and humoral immune responses. DTH was maximally depressed late, after refeeding had begun. Anti-TT responses were depressed early during starvation. Neither DTH nor anti-TT responses had returned to normal after a period of refeeding sufficient to restore weight. The data indicate that short-term acute nutritional deprivation may contribute to acquired immunodeficiency in patients undergoing surgery.
研究了短期急性营养剥夺和再喂养对大鼠免疫功能的影响。先前对钥孔戚血蓝蛋白致敏的动物被饥饿72小时，然后再喂养7天。用钥孔戚血蓝蛋白进行回忆皮肤试验以及用破伤风类毒素（TT）进行免疫接种，以评估迟发型超敏反应（DTH）和体液免疫反应。DTH在再喂养开始后的后期降至最低。抗TT反应在饥饿早期受到抑制。在经过足以恢复体重的一段时间再喂养后，DTH和抗TT反应均未恢复正常。数据表明，短期急性营养剥夺可能导致接受手术患者出现获得性免疫缺陷。
