Lal Barsha, Queener Hope M, Ostrin Lisa A
University of Houston College of Optometry, Houston, Texas, United States.
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):34. doi: 10.1167/iovs.66.6.34.
The purpose of this study was to investigate short-term effects of a range of low-dose atropine concentrations on static and dynamic pupil and accommodation metrics in young adults.
This double blinded study tested pupil and accommodation metrics at baseline and 1 hour and 24 hours after topical instillation of a single drop of placebo, 0.01%, 0.025%, 0.05%, and 0.1% atropine in the right eyes of 20 healthy adults (18-35 years). Static pupil diameter was measured under photopic, mesopic, and scotopic illumination, and dynamic responses were recorded as illumination changed from 0.3 to 140 lux using a pupillometer (MYAH). Peak constriction and dilation velocities were extracted. Accommodative lag and maximum accommodation were determined (WAM-5500) and dynamic responses were recorded for targets at 33 cm and 6 m (PowerRef). Dynamic responses were fitted with exponential functions to calculate amplitude, time constant, and peak velocities.
Static pupil diameters under all lighting conditions and dynamic metrics, including constriction amplitude and peak constriction and dilation velocities, showed significant dose-response effects at 1 hour and 24 hours (P < 0.05 for all). Maximum accommodation significantly decreased at 1 hour and 24 hours after atropine administration compared to placebo for all concentrations (P < 0.05 for all). Accommodative time constant increased and peak velocity decreased over 24 hours after atropine administration (P < 0.05). On the other hand, accommodative and disaccommodative amplitudes, disaccommodative time constant, and peak velocity did not significantly change after atropine administration (P > 0.05).
A single drop of 0.01%, 0.025%, 0.05%, and 0.1% atropine induced significant changes in static and dynamic pupil and accommodation metrics in a dose-dependent manner in young adults.
本研究旨在探讨一系列低剂量阿托品浓度对年轻成年人静态和动态瞳孔及调节指标的短期影响。
这项双盲研究在20名健康成年人（18 - 35岁）的右眼局部滴入一滴安慰剂、0.01%、0.025%、0.05%和0.1%阿托品后，于基线、1小时和24小时测试瞳孔和调节指标。在明视、中间视觉和暗视照明条件下测量静态瞳孔直径，并使用瞳孔计（MYAH）记录当照明从0.3勒克斯变化到140勒克斯时的动态反应。提取峰值收缩和扩张速度。测定调节滞后和最大调节力（WAM - 5500），并记录33厘米和6米处目标的动态反应（PowerRef）。动态反应采用指数函数拟合以计算幅度、时间常数和峰值速度。
在所有光照条件下的静态瞳孔直径以及包括收缩幅度、峰值收缩和扩张速度在内的动态指标，在1小时和24小时时均显示出显著的剂量反应效应（所有P < 0.05）。与安慰剂相比，所有浓度的阿托品给药后1小时和24小时，最大调节力均显著降低（所有P < 0.05）。阿托品给药后24小时内，调节时间常数增加，峰值速度降低（P < 0.05）。另一方面，阿托品给药后调节和去调节幅度、去调节时间常数以及峰值速度没有显著变化（P > 0.05）。
一滴0.01%、0.025%、0.05%和0.1%的阿托品以剂量依赖方式在年轻成年人中引起静态和动态瞳孔及调节指标的显著变化。
