Wang J P, Hsu M F, Huang L J
Thromb Res. 1985 Aug 15;39(4):501-10. doi: 10.1016/0049-3848(85)90173-2.
XC386 prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and persisted for at least six hours after the oral administration. XC386 was effective in preventing ADP-induced acute pulmonary thromboembolic death in mice at dose of 100 mg/kg. Aspirin and indomethacin had no effect on this model. XC386 also reduced the mortality rate in collagen- induced thromboembolic death at the same dose as aspirin and indomethacin (200 mg/kg). All three drugs caused no significant protection in endotoxin shock. XC386 was found to suppress collagen-induced platelet aggregation, but did not affect blood coagulation. In conclusion, XC386 was proved to be as effective as aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism.
XC386可延长清醒小鼠的尾部出血时间。这种作用呈剂量依赖性，口服给药后至少持续6小时。在100 mg/kg剂量下，XC386可有效预防小鼠因ADP诱导的急性肺血栓栓塞性死亡。阿司匹林和吲哚美辛对该模型无效。在与阿司匹林和吲哚美辛相同的剂量（200 mg/kg）下，XC386也降低了胶原蛋白诱导的血栓栓塞性死亡的死亡率。这三种药物在内毒素休克中均未产生显著的保护作用。研究发现XC386可抑制胶原蛋白诱导的血小板聚集，但不影响血液凝固。总之，已证明XC386在预防急性肺血栓栓塞死亡方面与阿司匹林和吲哚美辛同样有效。
