Wang J P, Hsu M F, Hsu T P, Teng C M
Thromb Res. 1985 Mar 15;37(6):669-79. doi: 10.1016/0049-3848(85)90196-3.
Capsaicin prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and maximal effect was observed at 3 hr after the oral administration. Capsaicin was effective in preventing death caused by ADP-induced acute pulmonary thromboembolism in mice at dose of 25 mg/kg, while aspirin and indomethacin had no effect at 200 mg/kg. Capsaicin also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death at dose of 25 and 50 mg/kg, respectively, and aspirin and indomethacin were also effective in these models but only when the dose was higher than 200 mg/kg. Capsaicin, aspirin or indomethacin could not protect mice from endotoxin shock. Capsaicin was found to suppress platelet aggregation markedly, but did not affect blood coagulation. In conclusion, capsaicin was proved to be more effective than aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism, and this effect could be due to its inhibition on platelet aggregation.
辣椒素可延长清醒小鼠的尾部出血时间。此效应呈剂量依赖性，口服给药后3小时观察到最大效应。辣椒素在25mg/kg剂量时可有效预防小鼠因ADP诱导的急性肺血栓栓塞所致死亡，而阿司匹林和吲哚美辛在200mg/kg时无此作用。辣椒素在25mg/kg和50mg/kg剂量时还分别降低了胶原和花生四烯酸钠诱导的血栓栓塞性死亡的死亡率，阿司匹林和吲哚美辛在这些模型中也有效，但仅当剂量高于200mg/kg时才有效。辣椒素、阿司匹林或吲哚美辛均不能保护小鼠免受内毒素休克。发现辣椒素可显著抑制血小板聚集，但不影响血液凝固。总之，已证明辣椒素在预防急性肺血栓栓塞死亡方面比阿司匹林和吲哚美辛更有效，且此效应可能归因于其对血小板聚集的抑制作用。
