Kim Jung-Tae, Lee Ka-Hyun, Lee Min-Woo
Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
PLoS One. 2025 Jun 10;20(6):e0325714. doi: 10.1371/journal.pone.0325714. eCollection 2025.
To investigate the impact of calcium dobesilate (CaD) on the macular microvasculature in patients with diabetic retinopathy (DR) using optical coherence tomography angiography.
In this retrospective study, patients with DR were divided into two groups: those treated with 1 g/day of CaD (Group 1) and those without CaD treatment (Group 2). Following the baseline, patients underwent two additional examinations at 3-month intervals for analysis. The vessel density of the superficial vascular complex (SVD) and deep vascular complex (DVD) were compared against prior assessments. Generalized linear mixed models analyzed factors associated with changes in SVD and DVD over time.
A total of 81 eyes were included: 39 in Group 1 and 42 in Group 2. The mean SVD was 21.8 ± 5.7% at baseline, 23.5 ± 6.5% at 3 months, and 23.3 ± 6.1% at 6 months in Group 1, respectively (P = 0.034), with significant changes observed from baseline to 3 months (P = 0.021), but not from 3 to 6 months (P = 0.745). The mean DVD was 18.2 ± 3.4% at baseline, 20.0 ± 3.9% at 3 months, and 19.9 ± 4.1% at 6 months in Group 1, respectively (P = 0.008), showing a significant increase from baseline to 3 months (P = 0.007), but not from 3 to 6 months (P = 0.825). Group 2 showed no significant changes over time in either SVD (P = 0.175) or DVD (P = 0.156). In Group 1, multivariate analysis identified DR severity as significantly associated with changes in SVD (estimate = 5.07, P = 0.016).
The administration of CaD positively influences macular microcirculation in DR patients, demonstrating its effectiveness even in advanced stages of the disease.
使用光学相干断层扫描血管造影术研究羟苯磺酸钙（CaD）对糖尿病视网膜病变（DR）患者黄斑部微血管系统的影响。
在这项回顾性研究中，DR患者被分为两组：每日接受1克CaD治疗的患者（第1组）和未接受CaD治疗的患者（第2组）。在基线检查之后，患者每隔3个月接受另外两次检查以进行分析。将浅表血管复合体（SVD）和深部血管复合体（DVD）的血管密度与先前的评估结果进行比较。使用广义线性混合模型分析与SVD和DVD随时间变化相关的因素。
共纳入81只眼：第1组39只，第2组42只。第1组的平均SVD在基线时为21.8±5.7%，3个月时为23.5±6.5%，6个月时为23.3±6.1%（P = 0.034），从基线到3个月有显著变化（P = 0.021），但从3个月到6个月无显著变化（P = 0.745）。第1组的平均DVD在基线时为18.2±3.4%，3个月时为20.0±3.9%，6个月时为19.9±4.1%（P = 0.008），从基线到3个月有显著增加（P = 0.007），但从3个月到6个月无显著变化（P = 0.825）。第2组的SVD（P = 0.175）和DVD（P = 0.156）随时间均无显著变化。在第1组中，多变量分析确定DR严重程度与SVD变化显著相关（估计值 = 5.07，P = 0.016）。
CaD的给药对DR患者的黄斑微循环有积极影响，表明其即使在疾病晚期也有效。
