铅离子对兔肺泡巨噬细胞免疫功能的影响：体外利用51Cr对免疫吞噬作用和玫瑰花结形成进行定量分析
The effects of lead ion on immune function of rabbit alveolar macrophages: quantitation of immune phagocytosis and rosette formation by 51Cr in vitro.
作者信息
Zhou J, Xu Y H, Chang H F
出版信息
Toxicol Appl Pharmacol. 1985 May;78(3):484-7. doi: 10.1016/0041-008x(85)90256-x.
PMID:4049397
Abstract
Experiments by a 51Cr-labeling technique were performed to investigate the effects of lead (Pb2+) on immune phagocytosis and Fc-rosette formation of rabbit pulmonary alveolar macrophages (PAMs). Evidence is presented that Pb2+ at concentrations of 10(-3) and 10(-4)M could inhibit these functions of PAMs. The degree of inhibition corresponded to the concentration of this heavy metal ion in vitro.
摘要
采用⁵¹Cr标记技术进行实验，以研究铅（Pb²⁺）对兔肺泡巨噬细胞（PAM）免疫吞噬作用和Fc花环形成的影响。有证据表明，浓度为10⁻³和10⁻⁴M的Pb²⁺可抑制PAM的这些功能。抑制程度与体外该重金属离子的浓度相对应。
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