Kaminski E J, Fischer C A, Kennedy G L, Calandra J C
Br J Exp Pathol. 1977 Feb;58(1):9-12.
The intratracheal instillation of moderate doses of PbO to Long-Evans strain rats resulted in a significant increase in the number of recoverable pulmonary alveolar macrophages. The viability of recovered cells was remarkably constant throughout the experimental period of 40 days. The results obtained indicate a low order of toxicity of PbO to alveolar macrophages and show that the mucociliary escalator is a significant route of excretion of PbO from the respiratory tract. The in vitro survival of macrophages from PbO-treated rats was significantly reduced. Survival of cells from both treated and control animals was somewhat enhanced by the addition of formalinized lymphocytes to the culture medium. Morphological changes and evidence of phagocytosis are discussed.
向Long-Evans品系大鼠气管内滴注中等剂量的氧化铅，可使可回收的肺泡巨噬细胞数量显著增加。在整个40天的实验期内，回收细胞的活力相当稳定。所得结果表明氧化铅对肺泡巨噬细胞的毒性较低，并表明黏液纤毛运送系统是氧化铅从呼吸道排出的重要途径。经氧化铅处理的大鼠巨噬细胞在体外的存活时间显著缩短。向培养基中添加甲醛固定的淋巴细胞，可使处理组和对照组动物的细胞存活率均有所提高。文中讨论了形态学变化及吞噬作用的证据。
