Megarioti Amalia H, Deol Kirandeep K, Olzmann James A
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Curr Biol. 2025 Jun 9;35(11):R406-R409. doi: 10.1016/j.cub.2025.04.012.
A new study identifies the aldehyde dehydrogenase ALDH7A1 as a key regulator of ferroptosis. ALDH7A1 generates a pool of membrane-associated NADH, which is used by ferroptosis suppressor protein 1 to recycle the lipid antioxidant coenzyme Q and suppress ferroptosis.
一项新研究确定醛脱氢酶ALDH7A1是铁死亡的关键调节因子。ALDH7A1产生大量与膜相关的NADH，铁死亡抑制蛋白1利用这些NADH来循环利用脂质抗氧化剂辅酶Q并抑制铁死亡。
