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Evidence supporting 3(S)-3-hydroxyquinidine-associated cardiotoxicity.

作者信息

Bowers L D, Nelson K M, Connor R, Lais C J, Krauss E

出版信息

Ther Drug Monit. 1985;7(3):308-12. doi: 10.1097/00007691-198507030-00013.

DOI:10.1097/00007691-198507030-00013
PMID:4049469
Abstract
摘要

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1
Evidence supporting 3(S)-3-hydroxyquinidine-associated cardiotoxicity.支持3(S)-3-羟基奎尼丁相关心脏毒性的证据。
Ther Drug Monit. 1985;7(3):308-12. doi: 10.1097/00007691-198507030-00013.
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Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6.奎尼丁作为CYP3A4活性的探针：个体内变异性以及与基于探针的CYP1A2、CYP2C9、CYP2C19和CYP2D6检测方法缺乏相关性。
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Specific determination of quinidine and (3S)-3-hydroxyquinidine in human serum by high-pressure liquid chromatography.采用高压液相色谱法特异性测定人血清中的奎尼丁和(3S)-3-羟基奎尼丁。
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Elimination kinetic of high polar metabolites pool of quinidine from human serum.
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Disposition of 3-hydroxyquinidine in patients receiving initial intravenous quinidine gluconate for electrophysiology testing of ventricular tachycardia.接受初始静脉注射葡萄糖酸奎尼丁以进行室性心动过速电生理检查的患者中3-羟基奎尼丁的处置情况。
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Lack of effect of smoking on the metabolism and pharmacokinetics of quinidine in patients.吸烟对患者奎尼丁代谢及药代动力学无影响。
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Accumulation of 3-hydroxyquinidine following chronic quinidine therapy.慢性奎尼丁治疗后3-羟基奎尼丁的蓄积
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