识别依赖于N-乙酰神经氨酸的抗原的冷反应性抗体。

Cold reacting antibodies recognizing antigens dependent on N-acetylneuraminic acid.

作者信息

Staub C A

出版信息

Transfusion. 1985 Sep-Oct;25(5):414-6. doi: 10.1046/j.1537-2995.1985.25586020112.x.

DOI:10.1046/j.1537-2995.1985.25586020112.x

Abstract

Serum from a 75-year-old man with lymphoproliferative disease was found to contain a persistent cold agglutinin meeting most of the characteristics of examples of anti-Gd reported previously. It differed, however, in that it contained IgG and IgM components and its reactivity was not inhibited by sialyllactose. A search of random serums containing cold agglutinins was undertaken to determine the incidence of antibodies to antigens dependent on N-acetylneuraminic acid. Two further examples were found in 47 serums containing cold agglutinins. One of these also demonstrated a Gd or "Gd-like" specificity. The other appeared to be an anti-Pr.

摘要

一名患有淋巴增生性疾病的75岁男性的血清中发现含有一种持续存在的冷凝集素，该冷凝集素符合先前报道的抗Gd实例的大多数特征。然而，它的不同之处在于它含有IgG和IgM成分，并且其反应性不受唾液乳糖抑制。对含有冷凝集素的随机血清进行了搜索，以确定依赖于N-乙酰神经氨酸的抗原抗体的发生率。在47份含有冷凝集素的血清中又发现了另外两个实例。其中一个也表现出Gd或“Gd样”特异性。另一个似乎是抗Pr。