Wang Weiwei, Xu Jianzhong, Fujimoto Tomotaka, Pouleur Anne-Catherine, Vancraeynest David, Wang Jiguang, Zen Kan, Stoenoiu Maria Simona, Persu Alexandre
Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Department of Urology, 302 Hospital of China Guizhou Aviation Industry Group, Anshun, Guizhou, China.
Hypertens Res. 2025 Jun 10. doi: 10.1038/s41440-025-02248-2.
A significant knowledge gap exists regarding characteristics of fibromuscular dysplasia (FMD) in Asian patients compared to Caucasian populations. This meta-analysis evaluated FMD characteristics in Asia (PROSPERO ID: CRD42024596516). PubMed, EMBASE, Cochrane Library, Web of Science, VIP, CNKI, and Wanfang databases were searched for observational studies after January 1, 2000, focusing on FMD in Asian populations. Twenty-four studies including 1254 Asian participants (1059 Chinese, 134 Japanese, and 61 others) were analyzed. Among Asian FMD patients, 59.0% (95% CI: 54.3-63.5%) were women, and mean age at FMD diagnosis was 28.6 years (26.7-30.6 years). Multifocal FMD was diagnosed in 38.4% (28.5-48.8%) of participants, and multivessel FMD in 12.7% (4.6-23.6%). Aneurysms and dissections were reported in 13.5% (7.8-20.4%) and 9.0% (1.8-19.9%) of participants, respectively. 99.9% (98.6-100.0%) of patients were hypertensive, 7.6% (5.3-10.2%) had a history of stroke and 40.3% (22.2-59.8%) reported headache. Bilateral renal artery involvement was documented in 17.9% (13.5-22.6%) of participants, and renal atrophy in 29.9% (24.4-35.6%). Compared with Japanese patients, Chinese patients were younger (26.2 vs. 36.2 years, P < 0.001). Furthermore, the proportion of women (59.4% vs. 64.3%, P = 0.334), and multifocal FMD (33.4% vs. 51.6%, P = 0.085) tended to be lower in Chinese versus Japanese patients. In conclusion, compared to published data in Caucasian patients, Asian FMD patients were younger, more often men, with focal FMD, and had lower rates of multivessel involvement, aneurysms, and dissections. Similar trends were found both in Chinese and Japanese patients. Our meta-analysis showed that compared to published data in Caucasian patients, Asian patients with FMD were younger, more often men, with focal FMD, and had lower rates of multivessel involvement, aneurysms, and dissections. Similar trends were found both in Chinese and Japanese patients.
与白种人群相比，亚洲患者纤维肌发育异常（FMD）的特征存在显著的知识空白。本荟萃分析评估了亚洲地区FMD的特征（PROSPERO编号：CRD42024596516）。检索了PubMed、EMBASE、Cochrane图书馆、Web of Science、维普、知网和万方数据库中2000年1月1日之后的观察性研究，重点关注亚洲人群的FMD。分析了24项研究，包括1254名亚洲参与者（1059名中国人、134名日本人以及61名其他国家的人）。在亚洲FMD患者中，59.0%（95%CI：54.3 - 63.5%）为女性，FMD诊断时的平均年龄为28.6岁（26.7 - 30.6岁）。38.4%（28.5 - 48.8%）的参与者被诊断为多灶性FMD，12.7%（4.6 - 23.6%）为多支血管FMD。分别有13.5%（7.8 - 20.4%）和9.0%（1.8 - 19.9%）的参与者报告有动脉瘤和夹层。99.9%（98.6 - 100.0%）的患者患有高血压，7.6%（5.3 - 10.2%）有中风病史，40.3%（22.2 - 59.8%）报告有头痛。17.9%（13.5 - 22.6%）的参与者记录有双侧肾动脉受累，29.9%（24.4 - 35.6%）有肾萎缩。与日本患者相比，中国患者更年轻（26.2岁对36.2岁，P < 0.001）。此外，中国患者中女性比例（59.4%对64.3%，P = 0.334）和多灶性FMD比例（33.4%对51.6%，P = 0.085）往往低于日本患者。总之，与白种人患者的已发表数据相比，亚洲FMD患者更年轻，男性更多，为局灶性FMD，多支血管受累、动脉瘤和夹层的发生率较低。在中国和日本患者中均发现了类似趋势。我们的荟萃分析表明，与白种人患者的已发表数据相比，亚洲FMD患者更年轻
