Kamel Rabab, Nocca Giuseppina, Mazzinelli Elena, Abd El-Karim Somaia S, Papa Valerio, Cacciotti Ilaria, Elkasabgy Nermeen A
Pharmaceutical Technology Department, National Research Centre, Cairo, 12622, Egypt.
Dipartimento Di Scienze Biotecnologiche Di Base, Cliniche Intensivologiche E Perioperatorie, Sezione Di Biochimica, Università Cattolica del Sacro Cuore (UCSC), Largo Francesco Vito 1, 00168, Rome, Italy.
AAPS PharmSciTech. 2025 Jun 10;26(5):167. doi: 10.1208/s12249-025-03157-w.
Clay minerals or nanoclays are layered aluminosilicate nanoparticles with unique physicochemical properties, excellent biocompatibility, high surface area, lamellar structure, diverse ion-exchange capacity, tuneable surface chemistry enabling them to form different intermolecular interactions which offer supreme prospects for optimized pharmaceutical applications. This review article dives into the key characteristics of different types of nanoclays like Halloysite, Kaolinite, Sepiolite, Montmorillonite, Bentonite and Laponite, highlighting their possible exploitation within the pharmaceutical landscape. Also, the review describes the recent advances in nanoclay-based drug delivery systems and discusses the role of nanoclays as drug carriers and their use in tissue engineering and gene therapy. Nanoclays, are used to modulate drug release and stabilize the loaded active molecules as well as to enhance drug loading. Interdisciplinary research, advanced characterization techniques, and careful formulation designs are required to augment the use of nanoclays in various pharmaceutical applications. Despite the faced challenges, research on nanoclay-based drug delivery systems is growing. With targeted research and development, nanoclays are poised to redefine the biomedical domain, offering tailored and efficient therapies for a multitude of diseases.
粘土矿物或纳米粘土是具有独特物理化学性质的层状铝硅酸盐纳米颗粒，具有优异的生物相容性、高比表面积、层状结构、多样的离子交换能力、可调节的表面化学性质，使其能够形成不同的分子间相互作用，为优化药物应用提供了绝佳前景。本文综述深入探讨了不同类型纳米粘土（如埃洛石、高岭土、海泡石、蒙脱石、膨润土和锂皂石）的关键特性，突出了它们在药物领域的潜在应用。此外，综述还介绍了基于纳米粘土的药物递送系统的最新进展，并讨论了纳米粘土作为药物载体的作用及其在组织工程和基因治疗中的应用。纳米粘土可用于调节药物释放、稳定负载的活性分子以及提高药物负载量。需要跨学科研究、先进的表征技术和精心的制剂设计来扩大纳米粘土在各种药物应用中的使用。尽管面临挑战，但基于纳米粘土的药物递送系统的研究仍在不断发展。通过有针对性的研发，纳米粘土有望重新定义生物医学领域，为多种疾病提供定制化且高效的治疗方法。
