Pertseva M N, Kuznetsova L A, Plesneva S A
Tsitologiia. 1985 Jul;27(7):750-5.
The functional development of hormone-sensitive adenylate cyclase system of rat skeletal muscles was studied. It was shown that within 15-17 embryonic days the plasma membrane of the muscle cell contains catecholamine-sensitive adenylate cyclase (isoproterenol greater than epinephrine greater than norepinephrine) which on these ontogenetic stages is represented by functionally active catalytic, regulatory and receptory components. The coupling component, which, according to the authors' view, is presumably an independent (fourth) functional subunit of adenylate cyclase system, is formed only in the postnatal period. A suggestion is put forward that the above process is due to the fact that guanyl nucleotide-binding protein(s) responsible in the mature target cell for the coupling of receptory and catalytic components may appear in the membrane only after birth.
对大鼠骨骼肌激素敏感腺苷酸环化酶系统的功能发育进行了研究。结果表明，在胚胎第15 - 17天内，肌细胞膜含有儿茶酚胺敏感的腺苷酸环化酶（异丙肾上腺素＞肾上腺素＞去甲肾上腺素），在这些个体发育阶段，其由功能活跃的催化、调节和受体成分组成。据作者认为，作为腺苷酸环化酶系统推测的独立（第四）功能亚基的偶联成分，仅在出生后时期形成。有人提出，上述过程是由于负责成熟靶细胞中受体和催化成分偶联的鸟苷酸结合蛋白可能仅在出生后才出现在膜中。
