Vaglini M, Andreola S, Attili A, Belli F, Marolda R, Nava M, Prada A, Santinami M, Cascinelli N
Tumori. 1985 Aug 31;71(4):355-9. doi: 10.1177/030089168507100406.
From February 1982 to December 1983, 42 patients affected by neoplasms of the limbs were treated at the Istituto Nazionale Tumori of Milan by hyperthermic antiblastic perfusion in extracorporeal circulation at the temperature of 40-41 degrees C for 1 h. Thirty-two were affected by melanoma, 4 by osteogenic sarcoma, 2 by squamous-cell carcinoma, 1 by liposarcoma, 1 by hemangiopericytoma, 1 by clear-cell sarcoma and 1 by Kaposis's sarcoma. As regards the immediate response, a complete plus partial remission rate of 88% without any major complication was obtained. The follow-up period is too short for any considerations about overall survival. However, because of these good clinical results we consider this method able to locally control the evolution of neoplasms of the extremities, allowing in many cases a limb salvage.
1982年2月至1983年12月，米兰国立肿瘤研究所对42例肢体肿瘤患者进行了体外循环热疗抗瘤灌注治疗，温度为40 - 41摄氏度，持续1小时。其中32例为黑色素瘤，4例为骨肉瘤，2例为鳞状细胞癌，1例为脂肪肉瘤，1例为血管外皮细胞瘤，1例为透明细胞肉瘤，1例为卡波西肉瘤。关于即时反应，获得了88%的完全缓解加部分缓解率，且无任何严重并发症。随访期太短，无法对总生存期进行任何评估。然而，鉴于这些良好的临床结果，我们认为该方法能够局部控制肢体肿瘤的进展，在许多情况下可实现保肢。
