Monticelli G, Santori F S, Folliero A, Ghera S, Cavaliere R, Di Fillippo F, Cavallaro A
Ital J Orthop Traumatol. 1983 Jun;9(2):167-80.
The authors describe the theoretical principles and the experimental and clinical investigations that form the basis for the technique of selective hyperthermic perfusion of the limbs, with or without the addition of antiblastic agents. Neoplastic cells are much more sensitive to heat than normal cells, undergoing necrosis at a temperature of 42.5 to 43 degrees C. The authors discuss the histological appearances and the clinical results obtained in the treatment of 29 cases of malignant neoplasms of the limbs in which antiblastic hyperthermic perfusion was carried out one month before surgical removal of the neoplasm. The long term results show that antiblastic hyperthermic perfusion significantly reduces the risk of local recurrences in cases of resection and in some cases enables amputations rather than disarticulations to be performed. This type of treatment is particularly indicated in the highly undifferentiated and aggressive forms such as osteosarcoma, malignant fibrous histiocytoma, adamantinoma, fibrosarcoma, giant-cell sarcoma, Ewing's tumour, and synovioma.
作者描述了肢体选择性热灌注技术的理论原理、实验研究和临床研究，该技术可添加或不添加抗瘤药物。肿瘤细胞比正常细胞对热敏感得多，在42.5至43摄氏度的温度下会发生坏死。作者讨论了对29例肢体恶性肿瘤进行抗瘤热灌注治疗的组织学表现和临床结果，这些患者在手术切除肿瘤前一个月进行了抗瘤热灌注。长期结果表明，抗瘤热灌注显著降低了切除病例中局部复发的风险，在某些情况下，能够进行截肢而非关节离断术。这种治疗方法特别适用于高度未分化和侵袭性的肿瘤类型，如骨肉瘤、恶性纤维组织细胞瘤、造釉细胞瘤、纤维肉瘤、巨细胞肉瘤、尤因肉瘤和滑膜瘤。
