Nezamzadeh Fatemeh, Saçıntı Koray Görkem, Esmailkhani Aylin, Kargın Özden, Amini Mohammad Esmaeil, Sönmezer Murat, Bialvaei Abed Zahedi
Islamic Azad University Faculty of Medicine, Tonekabon, Iran.
Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Türkiye.
J Turk Ger Gynecol Assoc. 2025 Jun 10;26(2):130-141. doi: 10.4274/jtgga.galenos.2024.2024-5-2.
Multiple sclerosis (MS) is an autoimmune disease that involves the central nervous system. MS is prevalent among young adults and progressively destroys axons and myelin. Individuals with MS often experience complications, such as lower urinary tract dysfunction, urinary tract infections (UTIs) and sexual dysfunction. In young adults MS may cause sexual dysfunction and infertility, which worsens as the disease progresses. The available evidence from different studies (microbiological and clinical studies, retrieved from PubMed and Scopus databases) on possible microbial pathogens causing MS was reviewed. Lower urinary tract dysfunction, UTIs and sexual dysfunction were investigated in people with MS. Over the past two decades advances in MS treatment have significantly slowed disease progression and altered its natural history. However, UTI and sexual dysfunction continue to pose substantial challenges for affected patients. As there is a causal relationship between UTIs and corticosteroid use during outbreaks, awareness of essential complications of MS, such as UTIs and infertility, is crucial for prevention, early diagnosis, and adequate management.
多发性硬化症（MS）是一种累及中枢神经系统的自身免疫性疾病。MS在年轻人中很常见，会逐渐破坏轴突和髓鞘。患有MS的个体常出现并发症，如下尿路功能障碍、尿路感染（UTIs）和性功能障碍。在年轻人中，MS可能导致性功能障碍和不孕，且随着疾病进展情况会恶化。我们回顾了从PubMed和Scopus数据库检索到的不同研究（微生物学和临床研究）中关于可能导致MS的微生物病原体的现有证据。对患有MS的人群的下尿路功能障碍、UTIs和性功能障碍进行了调查。在过去二十年中，MS治疗的进展显著减缓了疾病进展并改变了其自然病程。然而，UTI和性功能障碍仍然给受影响的患者带来巨大挑战。由于在疾病发作期间UTIs与皮质类固醇的使用之间存在因果关系，了解MS的重要并发症，如UTIs和不孕，对于预防、早期诊断和适当管理至关重要。
