16至20岁时较高的体重指数与男性成年后患多发性硬化症的风险增加有关。
Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among men.
作者信息
Xu Yin, Hiyoshi Ayako, Brand Judith S, Smith Kelsi A, Bahmanyar Shahram, Alfredsson Lars, Olsson Tomas, Montgomery Scott
机构信息
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden/Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
Mult Scler. 2021 Jan;27(1):147-150. doi: 10.1177/1352458520928061. Epub 2020 Jun 8.
BACKGROUND
Evidence for the association between body mass index (BMI) and multiple sclerosis (MS) among men remains mixed.
OBJECTIVE AND METHODS
Swedish military conscription and other registers identified MS after age of 20 years and BMI at ages 16-20 years ( = 744,548).
RESULTS
Each unit (kg/m) BMI increase was associated with greater MS risk (hazard ratio and 95% confidence interval = 1.034, 1.016-1.053), independent of physical fitness (1.021, 1.001-1.042). Categorised, overweight and obesity were associated with statistically significant raised MS risk compared to normal weight, but not after adjustment for physical fitness.
CONCLUSION
MS risk rises with increasing BMI, across the entire BMI range.
背景
男性体重指数（BMI）与多发性硬化症（MS）之间关联的证据仍存在分歧。
目的与方法
瑞典征兵记录及其他登记资料确定了20岁以后患多发性硬化症的情况以及16 - 20岁时的体重指数（n = 744,548）。
结果
BMI每增加一个单位（kg/m²），患MS的风险就更高（风险比及95%置信区间 = 1.034, 1.016 - 1.053），与身体素质无关（1.021, 1.001 - 1.042）。分类来看，与正常体重相比，超重和肥胖与MS风险显著升高相关，但在调整身体素质后则不然。
结论
在整个BMI范围内，MS风险随BMI升高而增加。
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