探索转录组数据库：揭示低级别胶质瘤中昼夜节律基因的破坏。

Department of Neurosurgery, The First Hospital of Shanxi Medical University, Taiyuan, 030012, China.

Department of Medical Engineering, Air Force Medical Center, PLA, Beijing, 100142, China.

Sci Rep. 2024 Jul 23;14(1):16960. doi: 10.1038/s41598-024-67559-9.

The study explored the role of circadian rhythm genes (CRGs) in lower grade glioma (LGG) development and found that certain genes, such as CRY1, NPAS2, and RORB, were associated with increased or decreased risk of LGG. The study also investigated the correlation between CRGs and immune cell infiltration, revealing a negative association with macrophage infiltration and a positive correlation with B cell and CD8 + T cell infiltration. Additionally, the study identified major mutated CRGs, including PER2, BMAL1, CLOCK, and BMAL2, and their potential interaction with other CNS-associated genes. The study suggests that CRGs play a crucial role in immune response and tumorigenesis in LGG patients and warrants further investigation.

该研究探讨了昼夜节律基因（CRGs）在低级别胶质瘤（LGG）发展中的作用，发现某些基因，如 CRY1、NPAS2 和 RORB，与 LGG 的风险增加或降低有关。该研究还调查了 CRGs 与免疫细胞浸润之间的相关性，结果表明其与巨噬细胞浸润呈负相关，与 B 细胞和 CD8+T 细胞浸润呈正相关。此外，该研究还鉴定了主要突变的 CRGs，包括 PER2、BMAL1、CLOCK 和 BMAL2，以及它们与其他中枢神经系统相关基因的潜在相互作用。该研究表明，CRGs 在 LGG 患者的免疫反应和肿瘤发生中起着关键作用，值得进一步研究。