Adesuyi Emmanuel O, Attah Cynthia A, Ige Oluwatosin A, Attamah Confidence C, Jimoh Khadijah A, Olabode Opeoluwa O, Akingbade Oluwadamilare, Adeagbo Ayobami O, Akinokun Rafiat, Ilesanmi Esther, Oyeleke Mary I, Dairo Abiodun E, Tola Yetunde O
Institute of Nursing Research Osogbo Osun Nigeria.
College of Health and Care Professions Birmingham City University Birmingham UK.
Public Health Chall. 2025 Feb 24;4(1):e70036. doi: 10.1002/puh2.70036. eCollection 2025 Mar.
To investigate the level of stigma, medication adherence and resilience among recently diagnosed people living with HIV/AIDS (PLWHA) and explore the relationship between medication adherence, stigmatization and resilience.
DESIGN/METHOD: This is a convergent-parallel mixed-method design involving both qualitative and quantitative research methodologies. The quantitative aspect utilized a cross-sectional design among 200 PLWHA at the anti-retroviral therapy clinic of the Lagos University Teaching Hospital, Lagos, Nigeria, whereas the qualitative part entailed semi-structured, in-depth interviews of 26 PLWHA. Spearman's rho correlation was used to explore the relationship between medication adherence, stigmatization and resilience, and qualitative data were analysed using thematic analysis.
Four themes emerged from the qualitative analysis, including building resilience, experiences relating to diagnosis, experiences related to treatment and factors facilitating medication adherence. Overall, 113 (57%) experienced a high level of stigma, 149 (76%) reported high medication adherence, and above average 115 (57.2%) demonstrated high resilience.
In this study, PLWHA in Nigeria who recently received their diagnosis experienced a high level of stigma, resilience and medication adherence. However, nearly one-third of the participants were non-adherent to medication due to several reasons. This noteworthy proportion of non-adherence needs to be addressed while improving resilience and reducing stigmatization.
调查近期确诊的艾滋病毒/艾滋病感染者（PLWHA）的耻辱感水平、药物依从性和恢复力，并探讨药物依从性、耻辱感和恢复力之间的关系。
设计/方法：这是一项采用定性和定量研究方法的收敛平行混合方法设计。定量方面在尼日利亚拉各斯大学教学医院抗逆转录病毒治疗诊所对200名PLWHA采用横断面设计，而定性部分则对26名PLWHA进行半结构化深入访谈。使用斯皮尔曼等级相关来探讨药物依从性、耻辱感和恢复力之间的关系，并使用主题分析对定性数据进行分析。
定性分析得出四个主题，包括建立恢复力、与诊断相关的经历、与治疗相关的经历以及促进药物依从性的因素。总体而言，113人（57%）经历了高水平的耻辱感，149人（76%）报告药物依从性高，115人（57.2%）表现出高于平均水平的高恢复力。
在本研究中，尼日利亚近期确诊的PLWHA经历了高水平的耻辱感、恢复力和药物依从性。然而，近三分之一的参与者由于多种原因未坚持服药。在提高恢复力和减少耻辱感的同时，需要解决这一值得注意的不依从比例问题。
