Sahrizan Nur Shaheera Aidilla, Yahya Noorazrul, Law Zhe Kang, Wan Zaidi Wan Asyraf, Nabilah Ismail Umi, Afifah Naela Himayati, Azri Amirul, Abdul Manan Hanani
Makmal Pemprosesan Imej Kefungsian (Functional Image Processing Laboratory), Department of Radiology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Diagnostic Imaging and Radiotherapy Program, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Neurol. 2025 May 27;16:1456146. doi: 10.3389/fneur.2025.1456146. eCollection 2025.
Stroke can result in a wide range of impairments, with sensorimotor dysfunction being among the most common, particularly when the sensorimotor network (SMN) is affected. As the SMN plays a critical role in movement control and coordination, understanding the changes in this network post-stroke is essential for informing recovery and rehabilitation strategies.
A systematic review was conducted following PRISMA guidelines. Two electronic databases, PubMed and Scopus, were searched for relevant studies investigating the effects of stroke on the SMN across different phases of recovery. Reference lists of selected articles were also reviewed using Google Scholar. A total of 20 eligible studies involving 618 stroke patients and 606 healthy controls were included.
The review revealed consistent findings of altered functional connectivity within the SMN following stroke. Despite initial impairments, most studies reported improvement in SMN connectivity over time, attributed to compensatory mechanisms, cortical reorganisation, and functional rewiring. Stroke location significantly influenced recovery outcomes. Supratentorial strokes were associated with poorer motor assessments and slower recovery, while infratentorial strokes had comparatively better outcomes. Lesions in the pontine region were found to cause severe disturbances in both sensory and motor functions depending on lesion extent.
The findings underscore the brain's capacity for neuroplasticity and reorganisation following stroke. Understanding the temporal and spatial changes in the SMN post-stroke can inform more targeted and effective rehabilitation strategies. These insights are crucial for tailoring interventions that align with individual stroke profiles and promote optimal functional recovery.
中风可导致多种损伤，其中感觉运动功能障碍最为常见，尤其是当感觉运动网络（SMN）受到影响时。由于SMN在运动控制和协调中起着关键作用，了解中风后该网络的变化对于制定康复和恢复策略至关重要。
按照PRISMA指南进行了系统综述。在两个电子数据库PubMed和Scopus中检索了相关研究，这些研究调查了中风在不同恢复阶段对SMN的影响。还使用谷歌学术对所选文章的参考文献列表进行了审查。共纳入了20项符合条件的研究，涉及618名中风患者和606名健康对照。
综述揭示了中风后SMN内功能连接改变的一致发现。尽管最初存在损伤，但大多数研究报告称，随着时间的推移，SMN连接性有所改善，这归因于补偿机制、皮质重组和功能重新布线。中风部位显著影响恢复结果。幕上中风与较差的运动评估和较慢的恢复相关，而幕下中风的结果相对较好。根据病变范围，发现脑桥区域的病变会导致感觉和运动功能的严重紊乱。
这些发现强调了中风后大脑的神经可塑性和重组能力。了解中风后SMN的时空变化可以为更有针对性和有效的康复策略提供信息。这些见解对于制定与个体中风情况相匹配的干预措施并促进最佳功能恢复至关重要。
