Chao Xiuhua, Li Jinye, Luo Jianfen, Liu Xianqi, Fan Zhaomin, Wang Haibo, Xu Lei
Department of Otolaryngology-Head and Neck Surgery Shandong Provincial ENT Hospital, Shandong University Jinan People's Republic of China.
Shandong Provincial ENT Institute Jinan People's Republic of China.
Laryngoscope Investig Otolaryngol. 2025 Jun 10;10(3):e70176. doi: 10.1002/lio2.70176. eCollection 2025 Jun.
To investigate neural responsiveness to electrical stimulation in children with common cavity deformity (CCD) after cochlear implantation (CI), compare these responses to those in children with normal cochlea, and analyze the influence of cavity volume and electrode position on these responses.
This is a case-control study. Participant included nine children with CCD and 11 children with normal cochlea. For each participant, electrically evoked compound action potentials (ECAPs) were measured, and input/output (I/O) functions were analyzed. The volume of the CCD, electrode to the fundus of the internal auditory canal (E-IAC) distance, and inner wall (E-IW) distance were measured on preoperative and postoperative imaging for children with CCD. Linear mixed-effects models (LMM) explored group differences and the influences of volume, E-IAC distance, and E-IW distance on ECAP responses for children with CCD.
Children with CCD exhibited significantly higher ECAP thresholds and lower amplitudes than those with normal cochlea. The E-IAC distance has a significant influence on the ECAP threshold and maximum amplitude ( < 0.05), but no significant effect on the I/O function slopes ( > 0.05). Neither cavity volume nor E-IW distance had a significant effect on ECAP responses ( > 0.05). Most children in the CCD group achieved open-set speech perception, but their word and sentence recognition rates were significantly lower than those in the Control group ( < 0.01).
Our findings demonstrated that there were a certain number of residual CNs in children with CCD; however, these nerves exhibited poorer responsiveness to electrical stimulation compared to children with a normal cochlea. Electrodes placed closer to the IAC fundus elicited stronger ECAP responses for children with CCD, which emphasized the importance of surgical strategies that minimize the distance between electrode contacts and residual cochlear nerve structures. 3.
研究人工耳蜗植入（CI）后共同腔畸形（CCD）儿童对电刺激的神经反应，将这些反应与正常耳蜗儿童的反应进行比较，并分析腔体积和电极位置对这些反应的影响。
这是一项病例对照研究。参与者包括9名CCD儿童和11名正常耳蜗儿童。对每位参与者测量电诱发复合动作电位（ECAP），并分析输入/输出（I/O）函数。对CCD儿童在术前和术后成像上测量CCD的体积、电极到内耳道底部（E-IAC）的距离以及内壁（E-IW）的距离。线性混合效应模型（LMM）探讨了组间差异以及体积、E-IAC距离和E-IW距离对CCD儿童ECAP反应的影响。
CCD儿童的ECAP阈值显著高于正常耳蜗儿童，振幅显著低于正常耳蜗儿童。E-IAC距离对ECAP阈值和最大振幅有显著影响（<0.05），但对I/O函数斜率无显著影响（>0.05）。腔体积和E-IW距离对ECAP反应均无显著影响（>0.05）。CCD组的大多数儿童实现了开放式言语感知，但其单词和句子识别率显著低于对照组（<0.01）。
我们的研究结果表明，CCD儿童存在一定数量的残余听神经；然而，与正常耳蜗儿童相比，这些神经对电刺激的反应较差。对于CCD儿童，电极放置得越靠近IAC底部，诱发的ECAP反应越强，这强调了尽量减少电极触点与残余耳蜗神经结构之间距离的手术策略的重要性。 3.
