Aryal Badri, Simmons Audrey, Ekkurthi Giri, Panthi Bibechana, Pena-Vizcarra Oscar Ruben
Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
Internal Medicine, Chicago Medical School, Rosalind Franklin University, Chicago, USA.
Cureus. 2025 May 9;17(5):e83811. doi: 10.7759/cureus.83811. eCollection 2025 May.
We present a case of antibody-confirmed drug-induced thrombocytopenia (DITP) caused by ceftriaxone. DITP is a rare but potentially life-threatening cause of isolated thrombocytopenia in the inpatient setting, often leading to critically low platelet levels. The underlying mechanism is believed to be an immune-mediated response, where drug-dependent antibodies bind to glycoproteins on the platelet membrane in the presence of the offending drug, resulting in platelet destruction and thrombocytopenia. We describe a case of ceftriaxone-induced thrombocytopenia in a patient being treated for aspiration pneumonia complicated by sepsis. To the best of our knowledge, only eight similar cases have been reported in the literature.
我们报告了一例由头孢曲松引起的抗体确诊的药物性血小板减少症（DITP）病例。DITP是住院患者孤立性血小板减少症的一种罕见但可能危及生命的病因，常导致血小板水平极低。其潜在机制被认为是一种免疫介导的反应，即药物依赖性抗体在存在致病药物的情况下与血小板膜上的糖蛋白结合，导致血小板破坏和血小板减少症。我们描述了一例正在接受因败血症并发吸入性肺炎治疗的患者发生头孢曲松诱导的血小板减少症的病例。据我们所知，文献中仅报道了8例类似病例。
