Piedra Abusharar Shady, Shah Neal, Patel Ravi, Jain Rohit, Polimera Hyma V
Internal Medicine, Penn State College of Medicine/ Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Cureus. 2019 May 17;11(5):e4688. doi: 10.7759/cureus.4688.
Drug-induced immune thrombocytopenia (DITP) is a rare, but potentially fatal cause of isolated thrombocytopenia. DITP is thought to occur when drug-dependent antibodies bind to the platelet membrane glycoproteins to activate platelet consumption signaling. Common implicated drugs include quinine/quinidine, penicillamines, valproic acid and cotrimoxazole. Ceftriaxone is a rare culprit with only six reported cases since 1991, of which only three were confirmed with drug-dependent antiplatelet antibodies. We describe a case of antibody confirmed ceftriaxone-induced immune thrombocytopenia after initiation of empiric antibiotic therapy for acute bacterial meningitis.
药物性免疫性血小板减少症（DITP）是孤立性血小板减少症的一种罕见但可能致命的病因。当药物依赖性抗体与血小板膜糖蛋白结合以激活血小板消耗信号传导时，就会发生DITP。常见的相关药物包括奎宁/奎尼丁、青霉胺、丙戊酸和复方新诺明。头孢曲松是一种罕见的致病药物，自1991年以来仅有6例报告病例，其中只有3例通过药物依赖性抗血小板抗体得到确诊。我们描述了一例在开始针对急性细菌性脑膜炎进行经验性抗生素治疗后，抗体确诊为头孢曲松诱导的免疫性血小板减少症的病例。
