微生物凝集素靶向黏液：一种糖生物信息学方法。

Microbial Lectin-Targeting Mucus: A Glycobioinformatic Approach.

作者信息

Lisacek Frédérique, Schnider Boris, Ohayon David, Imberty Anne

机构信息

Swiss Institute of Bioinformatics, Geneva, Switzerland.

Computer Science Department, UniGe, Geneva, Switzerland.

出版信息

Methods Mol Biol. 2025;2942:131-143. doi: 10.1007/978-1-0716-4627-4_11.

DOI:10.1007/978-1-0716-4627-4_11

PMID:40498312

Abstract

The motifs exposed on surface glycans of mucins serve as receptors to a range of proteins expressed by microorganisms. The specificity of microbial glycan-binding proteins, i.e., lectins, towards human mucin epitopes is the result of co-evolution. The binding of microbes to mucins is described in several databases hosted on the UniLectin portal. In particular, UniLectin3D provides structural details on the recognition process and LectomeXplore allows for the identification of putative lectins in the genomes of mucin-associated microbiome species. The usage of these resources is illustrated in this chapter.

摘要

粘蛋白表面聚糖上暴露的基序可作为多种微生物表达的蛋白质的受体。微生物聚糖结合蛋白（即凝集素）对人粘蛋白表位的特异性是共同进化的结果。微生物与粘蛋白的结合在UniLectin门户网站上托管的几个数据库中有所描述。特别是，UniLectin3D提供了识别过程的结构细节，而LectomeXplore则允许在粘蛋白相关微生物群落物种的基因组中鉴定推定的凝集素。本章将说明这些资源的用法。