粘蛋白型 O-聚糖及其在肠道稳态中的作用。
Mucin-type O-glycans and their roles in intestinal homeostasis.
机构信息
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
出版信息
Glycobiology. 2013 Sep;23(9):1026-37. doi: 10.1093/glycob/cwt045. Epub 2013 Jun 10.
Abstract
Mucin-type O-glycans are the primary constituents of mucins that are expressed on various mucosal sites of the body, especially the bacteria-laden intestinal tract. Mucins are the main components of mucus, which is secreted by goblet cells and forms a protective homeostatic barrier between the resident microbiota and the underlying immune cells in the colon. However, the specific role of mucin-type O-glycans in mucus barrier function has been uncertain. Recent studies utilizing mice deficient in key glycosyltransferases involved in O-glycan biosynthesis on intestinal mucins have underscored the importance of mucin-type O-glycosylation in mucus barrier function. This review will highlight recent advances in our understanding of mucin-type O-glycan function in the mucus barrier and how they promote mutualism with our resident microbiota.
摘要
黏蛋白型 O-聚糖是黏蛋白的主要成分，表达于机体的各种黏膜部位，特别是富含细菌的肠道。黏蛋白是由杯状细胞分泌的黏液的主要成分，在结肠中，它在定居菌群和下方免疫细胞之间形成保护性的体内平衡屏障。然而，黏蛋白型 O-聚糖在黏液屏障功能中的具体作用尚不确定。最近利用肠道黏蛋白中 O-聚糖生物合成关键糖基转移酶缺失的小鼠进行的研究强调了黏蛋白型 O-糖基化在黏液屏障功能中的重要性。本综述将重点介绍我们对黏蛋白型 O-聚糖在黏液屏障中的功能以及它们如何促进与我们常驻菌群共生的理解的最新进展。
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