急性髓系白血病、骨髓增生异常综合征和慢性粒单核细胞白血病患者骨髓CD8 T细胞中TCR库的比较分析
Comparative Analysis of the TCR Repertoire in Bone Marrow CD8 T Cells From Patients With Acute Myeloid Leukemia, Myelodysplastic Neoplasms, and Chronic Myelomonocytic Leukemia.
作者信息
Katsiki Kyriaki, Tasis Athanasios, Filia Anastasia, Kotsianidis Ioannis, Mitroulis Ioannis
机构信息
Translational Research and Laboratory Medicine Unit, First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
出版信息
Eur J Immunol. 2025 Jun;55(6):e51796. doi: 10.1002/eji.202551796.
Bone marrow CD8 T cells from patients with MDS and CMML show decreased TCR diversity compared to AML. Treatment with the hypomethylating agent azacitidine in MDS and CMML alters TCR repertoire of CD8 T cells without affecting TCR diversity.
与急性髓系白血病（AML）相比，骨髓增生异常综合征（MDS）和慢性粒单核细胞白血病（CMML）患者的骨髓CD8 T细胞显示出TCR多样性降低。在MDS和CMML中使用低甲基化药物阿扎胞苷进行治疗会改变CD8 T细胞的TCR库，而不影响TCR多样性。
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