骨髓增生异常综合征中骨髓CD8 + T细胞的单细胞分析揭示了与疾病进展和阿扎胞苷治疗反应相关的途径。
Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine.
作者信息
Tasis Athanasios, Papaioannou Nikos E, Grigoriou Maria, Paschalidis Nikolaos, Loukogiannaki Catherine, Filia Anastasia, Katsiki Kyriaki, Lamprianidou Eleftheria, Papadopoulos Vasileios, Rimpa Christina Maria, Chatzigeorgiou Antonios, Kourtzelis Ioannis, Gerasimou Petroula, Kyprianou Ioannis, Costeas Paul, Liakopoulos Panagiotis, Liapis Konstantinos, Kolovos Petros, Chavakis Triantafyllos, Alissafi Themis, Kotsianidis Ioannis, Mitroulis Ioannis
机构信息
Translational Research and Laboratory Medicine Unit, First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
出版信息
Cancer Res Commun. 2024 Dec 1;4(12):3067-3083. doi: 10.1158/2767-9764.CRC-24-0310.
Immunophenotypic analysis identified a BM CD57+CXCR3+ subset of CD8+ T cells associated with response to AZA in patients with MDS and AML. Single-cell RNA sequencing analysis revealed that IFN signaling is linked to the response to treatment, whereas TGF-β signaling is associated with treatment failure, providing insights into new therapeutic approaches.
免疫表型分析确定了骨髓中CD57⁺CXCR3⁺的CD8⁺T细胞亚群，其与骨髓增生异常综合征（MDS）和急性髓系白血病（AML）患者对阿扎胞苷（AZA）的反应相关。单细胞RNA测序分析显示，干扰素（IFN）信号传导与治疗反应相关，而转化生长因子-β（TGF-β）信号传导与治疗失败相关，这为新的治疗方法提供了思路。
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