Gribencha S V, Ignat'ev G M, Kirkin A F, Barinskiĭ I F
Vopr Virusol. 1985 May-Jun;30(3):358-62.
Experiments in CBA and BALB/c mice showed that after vaccination against rabies alongside with humoral immune response there developed a clone of cells sensitized to rabies antigen which, upon a secondary exposure to it, responded by increased blast formation. The immunological memory to the rabies antigen was found to be specific and to persist for up to 100 days (the observation period). Immunization of mice with rabies vaccine using various schedules and in combination with interferon inducers revealed no correlation between the lymphocyte blastogenesis parameters and virus-neutralizing antibody levels or the intensity of immunity to street rabies virus. The lymphocyte blasttransformation test with nonspecific mitogens may also be used for evaluation of the toxicity of new preparations.
在CBA和BALB/c小鼠身上进行的实验表明，接种狂犬病疫苗后，除了体液免疫反应外，还产生了对狂犬病抗原敏感的细胞克隆，再次接触该抗原时，这些细胞会通过增加母细胞形成做出反应。发现对狂犬病抗原的免疫记忆具有特异性，并且可持续长达100天（观察期）。使用不同方案并用干扰素诱导剂对小鼠进行狂犬病疫苗免疫，结果显示淋巴细胞母细胞生成参数与病毒中和抗体水平或对街狂犬病病毒的免疫强度之间没有相关性。用非特异性有丝分裂原进行的淋巴细胞转化试验也可用于评估新制剂的毒性。
