Gribencha S V, Reveneko N G, Barinskiĭ I F
Vopr Virusol. 1988 Sep-Oct;33(5):576-80.
Daily administration of vaccine as well as combined use of antirabies gamma-globulin and vaccine were shown not to induce the production of immune T-killers possessing protective properties in adoptive transfer in mice pre-infected with street rabies virus in contrast to a single administration of a shock dose of antigen. Immune splenocytes protected 31-43% of mice infected with street rabies virus in a dose of 2-4 im LD50 and did not protect the animals infected with a dose of 12 im-LD50. After combined administration of immune splenocytes and an interferon inducer (double-stranded RNA) the additive protective effect was observed.
与单次给予冲击剂量抗原相比，在预先感染街狂犬病毒的小鼠中进行过继转移时，每日接种疫苗以及联合使用抗狂犬病丙种球蛋白和疫苗均未诱导产生具有保护特性的免疫杀伤性T细胞。免疫脾细胞能保护31% - 43%感染2 - 4个免疫LD50剂量街狂犬病毒的小鼠，但不能保护感染12个免疫LD50剂量的动物。在联合给予免疫脾细胞和干扰素诱导剂（双链RNA）后，观察到了相加的保护作用。
