正丁基缩水甘油醚在大鼠和兔子体内的代谢
The metabolism of n-butyl glycidyl ether in the rat and rabbit.
作者信息
Eadsforth C V, Hutson D H, Logan C J, Morrison B J
出版信息
Xenobiotica. 1985 Jul;15(7):579-89. doi: 10.3109/00498258509045887.
[1-14C]Butyl glycidyl ether administered orally to male rats and rabbits (20 mg/kg) is rapidly absorbed and metabolized. Most of the administered compound, 87% (rat) and 78% (rabbit), is eliminated in the 0-24 urine. Major metabolites in the rat include 3-butoxy-2-hydroxypropionic acid (9%), 3-butoxy-2-acetylaminopropionic acid (23%) and butoxyacetic acid (10%). 3-Butoxy-2-hydroxypropionic acid (35%) and butoxyacetic acid (5%) are also major metabolites in the rabbit. Biotransformations of the glycidyl ether and their likely biochemical mechanisms are discussed.
给雄性大鼠和兔子口服[1-¹⁴C]丁基缩水甘油醚（20毫克/千克）后，其迅速被吸收并代谢。所给药化合物的大部分，大鼠为87%，兔子为78%，在0 - 24小时尿液中排出。大鼠体内的主要代谢产物包括3 - 丁氧基 - 2 - 羟基丙酸（9%）、3 - 丁氧基 - 2 - 乙酰氨基丙酸（23%）和丁氧基乙酸（10%）。3 - 丁氧基 - 2 - 羟基丙酸（35%）和丁氧基乙酸（5%）也是兔子体内的主要代谢产物。文中讨论了缩水甘油醚的生物转化及其可能的生化机制。
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