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Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

作者信息

Nordqvist M, Thakker D R, Vyas K P, Yagi H, Levin W, Ryan D E, Thomas P E, Conney A H, Jerina D M

出版信息

Mol Pharmacol. 1981 Jan;19(1):168-78.

PMID:7207460
Abstract
摘要

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Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.大鼠肝脏酶将屈和菲代谢为湾区二醇环氧化物。
Mol Pharmacol. 1981 Jan;19(1):168-78.
2
Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.大鼠肝脏酶将反式-1,2-二羟基-1,2-二氢 Chrysene 的（+）-和（-）-对映体立体选择性代谢为湾区 1,2-二醇-3,4-环氧化物非对映异构体。
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Mutagenicity and tumorigenicity of phenanthrene and chrysene epoxides and diol epoxides.
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Metabolism of (-)-trans-(3R, 4R)-dihydroxy-3,4-dihydrochrysene to diol epoxides by liver microsomes.肝脏微粒体将(-)-反式-(3R, 4R)-二羟基-3,4-二氢 Chrysene 代谢为二醇环氧化物。
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Highly tumorigenic bay-region diol epoxides from the weak carcinogen benzo[c]phenanthrene.来自弱致癌物苯并[c]菲的高致瘤性湾区二醇环氧化物。
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Fate of epoxides.环氧化物的命运
Adv Exp Med Biol. 1981;136 Pt A:39-52.

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