Li Qicheng, Sun Tianze, Liu Shiyan, Kou Yuhui, Han Na
Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing 100000, China; Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100000, China.
Department of Physiology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.
Int J Pharm. 2025 Aug 20;681:125832. doi: 10.1016/j.ijpharm.2025.125832. Epub 2025 Jun 9.
Bone aging diseases, including osteoporosis and osteoarthritis, present significant global health challenges, particularly in countries experiencing demographic aging. Conventional treatment strategies such as pharmacotherapy and lifestyle adjustments frequently yield suboptimal therapeutic outcomes and are carry risks of long-term adverse effects. In recent years, biomembrane-derived nanoparticles have emerged as promising candidates for advanced drug delivery systems to overcome these limitations. By encapsulating therapeutic agents within biomembranes (cell membrane, extracellular vesicles), these systems enhance biocompatibility, prolong circulation time, and enable targeted delivery to pathological sites. Moreover, biomembranes can be functionally modified to optimize their therapeutic performance. In this review, we explore the pathophysiology of bone aging diseases, current treatment approaches, and the development of biomembrane-derived nanoparticles, with a focus on their potential applications in osteoporosis and osteoarthritis. These innovative delivery systems offer the potential to improve treatment efficacy and minimize side effects, thereby laying the foundation for clinical translation in the future.
包括骨质疏松症和骨关节炎在内的骨老化疾病给全球健康带来了重大挑战，在人口老龄化的国家尤为如此。传统的治疗策略，如药物治疗和生活方式调整，往往产生不理想的治疗效果，并且存在长期不良反应的风险。近年来，生物膜衍生的纳米颗粒已成为先进药物递送系统的有前景的候选者，以克服这些局限性。通过将治疗剂封装在生物膜（细胞膜、细胞外囊泡）内，这些系统增强了生物相容性，延长了循环时间，并能够靶向递送至病理部位。此外，可以对生物膜进行功能修饰以优化其治疗性能。在本综述中，我们探讨了骨老化疾病的病理生理学、当前的治疗方法以及生物膜衍生的纳米颗粒的发展，重点关注它们在骨质疏松症和骨关节炎中的潜在应用。这些创新的递送系统有可能提高治疗效果并最小化副作用，从而为未来的临床转化奠定基础。
