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[霍奇金病放疗后遗症之双侧冠状动脉口狭窄及隐匿性甲状腺功能减退]

[Ostium stenosis of both coronary arteries and latent hypothyroidism as sequelae of radiotherapy in Hodgkin disease].

作者信息

Stegaru-Hellring B, Keller H, Bode H, Usadel K H, Wallwork J

出版信息

Z Kardiol. 1985 Aug;74(8):485-8.

PMID:4050000
Abstract

Premature arteriosclerosis following irradiation is a known experimental and clinical phenomenon. Although the heart was once considered a relatively radioresistant organ, now all components, including the coronary arteries, are recognised as possible targets of radiation injury. We present a 40-year-old women who received extensive neck and thoracic radiation for treatment of Hodgkin's disease. Ten years later she developed severe coronary artery disease with ostium stenosis of the left and right coronary arteries, as well as subclinical hypothyroidism.

摘要

放疗后过早出现动脉硬化是一种已知的实验和临床现象。尽管心脏曾被认为是相对抗辐射的器官,但现在包括冠状动脉在内的所有成分都被认为是辐射损伤的可能靶点。我们报告一名40岁女性,她因治疗霍奇金病接受了广泛的颈部和胸部放疗。十年后,她患上了严重的冠状动脉疾病,左、右冠状动脉开口狭窄,同时还有亚临床甲状腺功能减退。

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