Weber G, Fabbrini P, Resi L, Jones R, Vesselinovitch D, Wissler R W
Atherosclerosis. 1977 Apr;26(4):535-47. doi: 10.1016/0021-9150(77)90121-6.
Scanning and transmission microscopy were used to study aortic intima atherosclerotic lesions in Rhesus monkeys during both progression and regression phases. Scanning micrographs of severely atherosclerotic lesions showed areas of disjunctive endothelium and discontinuous basement membranes, frequently accompanied by red blood cells and other circulating elements adhering to the surface. Transmission micrographs also showed occasional areas of endothelial cell damage and loss with lipid-laden smooth muscle cells and foam cells beneath. Regressed lesions (affected by low-fat, low-cholesterol diet with or without cholestyramine) showed endothelial changes suggestive of reparative processes. Scanning micrographs showed flattened residual lesions with continous endothelial lining, while transmission microscopy disclosed interdigitated intercellular tight junctions and frequently reduplicated basement membranes.
利用扫描显微镜和透射显微镜研究了恒河猴主动脉内膜动脉粥样硬化病变在进展期和消退期的情况。严重动脉粥样硬化病变的扫描显微照片显示，内皮细胞分离和基底膜不连续的区域，常伴有红细胞和其他循环成分附着于表面。透射显微照片还显示，偶尔会出现内皮细胞损伤和缺失的区域，其下方有充满脂质的平滑肌细胞和泡沫细胞。消退性病变（受低脂、低胆固醇饮食影响，无论是否使用消胆胺）显示出提示修复过程的内皮变化。扫描显微照片显示残留病变变平，内皮衬里连续，而透射显微镜检查发现细胞间紧密连接相互交错，基底膜常重复出现。
