Reidy M A, Bowyer D E
Virchows Arch A Pathol Anat Histol. 1978 Mar 10;377(3):237-48. doi: 10.1007/BF00426933.
Young male rabbits were fed a diet containing 0.2% cholesterol for 4, 6, 12 and 20 weeks. At death the aortas of each animal were prepared for scanning electron microscopy (SEM) and the size of the atherosclerotic lesions surrounding the aortic ostia was measured by planimetry. Under SEM the early fatty lesions appeared as small discrete swelling of the endothelial cells. These cells were often larger than normal endothelial cells and their cell boundaries stained poorly with silver salts. Large confluent lesions were observed distal to the aortic ostia both 12 and 20 weeks after commencement of the diet but were still found to be endothelialized. No lesions however were observed immediately proximal to the entrance of an aortic branch. Haemodynamic forces, such as a high shear force, were presumably responsible for the localisation of these lesions.
给年轻雄性兔子喂食含0.2%胆固醇的饮食，持续4、6、12和20周。处死时，将每只动物的主动脉制备用于扫描电子显微镜（SEM）检查，并通过平面测量法测量围绕主动脉口的动脉粥样硬化病变的大小。在SEM下，早期脂肪病变表现为内皮细胞的小而离散的肿胀。这些细胞通常比正常内皮细胞大，并且它们的细胞边界用银盐染色不佳。在饮食开始后的12周和20周，在主动脉口远端观察到大量融合病变，但仍发现其被内皮化。然而，在主动脉分支入口紧邻的近端未观察到病变。血流动力学力量，如高剪切力，可能是这些病变定位的原因。
