Shaaban Hossam Eldin, Hara Kazuo, Haba Shin, Kuwahara Takamichi, Okuno Nozomi, Koda Hiroki, Urata Minako, Kondo Takashi, Yamamoto Yoshitaro, Okasha Hussein Hassan
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kasr Al-Aini School of Medicine, Cairo University, Cairo, Egypt.
Int J Gen Med. 2025 Jun 7;18:2941-2948. doi: 10.2147/IJGM.S520042. eCollection 2025.
BACKGROUNDS/AIMS: Tissue acquisition from splenic lesions is challenging. The role of endoscopic ultrasound in tissue acquisition for splenic lesions is not fully established due to paucity of published literature. This retrospective study evaluated the effectiveness and safety of endoscopic ultrasound-guided fine-needle aspiration/biopsy for splenic lesions.
Medical records of 18 patients who underwent EUS-FNA/B of splenic lesions at Aichi Cancer Center Hospital, Nagoya, Japan from February 2012 to June 2023 were retrospectively reviewed.
Eighteen patients with splenic lesions underwent EUS-FNA/B. Among them, 3 were diagnosed with malignant lesions and 15 with benign lesions. The diagnostic performance of EUS-FNA/B was excellent, with a diagnostic accuracy of 100% (18/18; CI, 81.5-100%), sensitivity of 100% (3/3; CI, 29.2-100%), and specificity of 100% (15/15; CI, 78.2-100%). A total of 34 lesions were sampled across all patients, including 24 splenic lesions, 6 lymph nodes, 2 pancreatic masses, and 2 hepatic focal lesions. Minor complications were observed in three patients: one case of post-procedural bleeding, one of self-limiting abdominal pain, and one case of transient fever that resolved within 24 hours with antibiotics.
EUS-FNA/B of splenic lesions demonstrated to be safe and of high diagnostic yield.
背景/目的：从脾脏病变获取组织具有挑战性。由于已发表文献较少，内镜超声在脾脏病变组织获取中的作用尚未完全确立。本回顾性研究评估了内镜超声引导下细针穿刺抽吸/活检用于脾脏病变的有效性和安全性。
回顾性分析了2012年2月至2023年6月在日本名古屋爱知癌症中心医院接受脾脏病变内镜超声引导下细针穿刺抽吸/活检的18例患者的病历。
18例脾脏病变患者接受了内镜超声引导下细针穿刺抽吸/活检。其中，3例被诊断为恶性病变，15例为良性病变。内镜超声引导下细针穿刺抽吸/活检的诊断性能优异，诊断准确率为100%（18/18；可信区间，81.5 - 100%），敏感性为100%（3/3；可信区间，29.2 - 100%），特异性为100%（15/15；可信区间，78.2 - 100%）。所有患者共取样34个病变，包括24个脾脏病变、6个淋巴结、2个胰腺肿块和2个肝脏局灶性病变。3例患者出现轻微并发症：1例术后出血，1例自限性腹痛，1例短暂发热，使用抗生素后24小时内缓解。
脾脏病变的内镜超声引导下细针穿刺抽吸/活检显示出安全性高且诊断率高。
