Song Yuxi, Jiang Xuejie, Hao Yu, Sun Rui, Bai Yunlong, Shao Guang, Ren Wanxia, Xia Cheng
Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.
Heilongjiang Mudanjiang Agricultural Reclamation Jin'ao Dairy Farming Specialized Cooperative, Mudanjiang, China.
Front Vet Sci. 2025 May 28;12:1609300. doi: 10.3389/fvets.2025.1609300. eCollection 2025.
Ketosis is a prevalent metabolic disease in dairy cows, characterized by adverse effects on both animal health and production performance. Propylene glycol (PG), recognized for its glucogenic properties, is widely utilized in the therapeutic management of ketosis. This study evaluated the efficacy of two PG-based treatment protocols in mitigating ketosis and enhancing the metabolic health of cows. Ninety cows were randomly allocated into three groups ( = 30 each): control (Group C, no PG), original PG protocol (Group O, 500 mL PG orally drenched once daily on days 0, 1, 2, 7, 8, and 9 post-calving), and novel PG protocol (Group N, 500 mL PG orally drenched once daily on days 0, 7, and 14 post-calving). Data were collected for body condition score, milk yield, metabolic biomarkers, and the incidence of ketosis from 14 (±3) days prepartum to 50 days postpartum. The results demonstrated that the novel PG protocol, compared with the control group, significantly enhanced energy metabolism by modulating glucose, insulin, and leptin levels while reducing -hydroxybutyric acid and non-esterified fatty acid concentrations ( < 0.05). Additionally, the novel PG protocol effectively decreased the incidence of ketosis (from 33.3% in Group C to 6.7% in Group N at 14 days postpartum), alleviated liver injury, and mitigated oxidative stress in dairy cows ( < 0.05). These findings underscore the potential of the novel PG protocol to improve metabolic health and reduce the risk of ketosis during the critical transition period in dairy cows. This offers a promising strategy for managing this condition in modern dairy production systems.
酮病是奶牛中一种普遍的代谢性疾病，其特征是对动物健康和生产性能均有不利影响。丙二醇（PG）因其生糖特性而闻名，被广泛用于酮病的治疗管理。本研究评估了两种基于PG的治疗方案在减轻奶牛酮病和改善其代谢健康方面的效果。90头奶牛被随机分为三组（每组 = 30头）：对照组（C组，不使用PG）、原始PG方案组（O组，在产后第0、1、2、7、8和9天每天口服灌服500 mL PG）和新型PG方案组（N组，在产后第0、7和14天每天口服灌服500 mL PG）。收集了从产前14（±3）天到产后50天的体况评分、产奶量、代谢生物标志物和酮病发病率的数据。结果表明，与对照组相比，新型PG方案通过调节葡萄糖、胰岛素和瘦素水平，同时降低β-羟基丁酸和非酯化脂肪酸浓度，显著增强了能量代谢（P < 0.05）。此外，新型PG方案有效降低了酮病的发病率（产后14天时，C组从33.3%降至N组的6.7%），减轻了奶牛的肝脏损伤并缓解了氧化应激（P < 0.05）。这些发现强调了新型PG方案在改善奶牛关键过渡期的代谢健康和降低酮病风险方面的潜力。这为现代奶牛生产系统中管理这种疾病提供了一种有前景的策略。
