Jung Yoon Kyung, Park Hyun Jeong, Hwang Hye Won, Lee Eun Sun, Ryu Rae Rim
J Korean Soc Radiol. 2025 May;86(3):438-444. doi: 10.3348/jksr.2024.0064. Epub 2025 Feb 25.
Pancreatic neuroendocrine tumors (PanNETs) are a rare type of pancreatic neoplasm. PanNETs with intraductal growth are considered extremely rare, and ductal involvement in NETs has been reported to correlate with aggressive clinical behavior. A 67-year-old male was referred to our hospital for further evaluation of a pancreatic tumor. Various imaging modalities, including ultrasonography, contrast-enhanced CT, MRI, and endoscopic ultrasonography (EUS), demonstrated a well-defined pancreatic mass in the head and body, primarily located within the main pancreatic duct with extension to the main portal vein. Histological diagnosis from an EUS-guided biopsy revealed a grade 3 well-differentiated NET. The patient was scheduled for surgery; however, multiple additional bone metastases were identified on F-fluorodeoxyglucose PET/CT. Although the presence of intraductal growth and portal vein invasion is uncommon in PanNETs, aggressive workup and treatment are essential in such cases.
胰腺神经内分泌肿瘤（PanNETs）是一种罕见的胰腺肿瘤类型。具有导管内生长的PanNETs被认为极其罕见，并且据报道神经内分泌肿瘤中的导管侵犯与侵袭性临床行为相关。一名67岁男性因胰腺肿瘤进一步评估被转诊至我院。包括超声、增强CT、MRI和内镜超声（EUS）在内的各种影像学检查显示，胰头和胰体有一个边界清晰的肿块，主要位于主胰管内并延伸至门静脉主干。EUS引导下活检的组织学诊断显示为G3高分化神经内分泌肿瘤。患者原定进行手术；然而，在F-氟脱氧葡萄糖PET/CT上发现了多处额外的骨转移。尽管导管内生长和门静脉侵犯在PanNETs中并不常见，但在此类病例中进行积极的检查和治疗至关重要。
