Yamamoto Hiroki, Hisamoto Teruyoshi, Omatsu Jun, Sato Shinichi
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, JPN.
Cureus. 2025 May 12;17(5):e83953. doi: 10.7759/cureus.83953. eCollection 2025 May.
Verruciform xanthoma (VX) is a rare benign tumor that usually occurs in the oral area or the urogenital region. Although VX sometimes arises in the oral space, VX on the lip is rare. The ratio of oral VX in chronic graft-versus-host disease (cGVHD) patients might be higher than that of the general population, and the frequency of lip cases may also be higher in cGVHD patients. In some cases, VX mimics malignant tumors such as verrucous carcinoma or squamous cell carcinoma. It is important to distinguish VX from malignant tumors to prevent excessive excision. Our case is a VX on the lower lip of a cGVHD patient. It was diagnosed by skin biopsy and treated by total excision. When we find a verrucous or papillary tumor, especially in a cGVHD patient, VX should be a candidate for diagnosis, as well as verruca vulgaris or verrucous carcinoma, to prevent unnecessary extensive excision.
疣状黄色瘤（VX）是一种罕见的良性肿瘤，通常发生在口腔区域或泌尿生殖区域。虽然VX有时出现在口腔部位，但唇部的VX较为罕见。慢性移植物抗宿主病（cGVHD）患者中口腔VX的比例可能高于一般人群，cGVHD患者唇部病例的发生率也可能更高。在某些情况下，VX会模仿恶性肿瘤，如疣状癌或鳞状细胞癌。将VX与恶性肿瘤区分开来以防止过度切除很重要。我们的病例是一名cGVHD患者下唇的VX。通过皮肤活检确诊，并进行了全切治疗。当我们发现疣状或乳头状肿瘤时，特别是在cGVHD患者中，除了寻常疣或疣状癌外，VX也应作为诊断的候选，以防止不必要的广泛切除。
