Musazadeh Vali, Hamidi Niloofar, Noormohammadi Morvarid, Shidfar Farzad
Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Curr Ther Res Clin Exp. 2025 Mar 26;102:100788. doi: 10.1016/j.curtheres.2025.100788. eCollection 2025.
Type 2 diabetes mellitus (T2DM) raises cardiovascular disease risk, but evidence on Berberis's impact is limited and inconsistent. This systematic review and meta-analysis aimed to assess effect of Berberis supplement on cardiovascular risk factors in patients with T2DM.
We extensively searched Embase, Web of Science, Scopus, PubMed, and the Cochrane Library for randomized controlled trials (RCTs) up to October 25, 2024. This study primarily assesses Berberis's impact on improving glycemic indices, with secondary measures including obesity, blood pressure and lipid profile parameters.
After reviewing 784 articles, we included data from eight RCTs involving 451 participants with T2DM. The results of meta-analysis indicated that Berberis administration significantly reduced weight (WMD: -2.25; 95% CI: -3.11 to -1.39), body mass index (BMI, WMD: -0.57; 95% CI: -0.98 to -0.17), TG (WMD: -19.32; 95% CI: -30.95 to -1.69), TC (WMD: -28.57; 95% CI: -30.22 to -21.51), LDL-C (WMD: -17.47; 95% CI: -24.18 to -10.75), FBS (WMD: -14.54; 95% CI: -23.83, -5.25), HbA1c (WMD: -0.65; 95% CI: -1.30, -0.00), HOMA-IR (WMD: -1.82; 95% CI: -3.60, -0.05), and insulin (WMD: -4.40; 95% CI: -7.15, -1.65). However, no statistically significant effect on blood pressure and HDL-C level was observed with Berberis intervention.
This meta-analysis hints at Berberis's potential benefits for T2DM. However, more extensive trials are needed to confirm its advantages definitively.
2型糖尿病（T2DM）会增加心血管疾病风险，但关于小檗属植物影响的证据有限且不一致。本系统评价和荟萃分析旨在评估小檗属植物补充剂对T2DM患者心血管危险因素的影响。
我们广泛检索了截至2024年10月25日的Embase、科学网、Scopus、PubMed和Cochrane图书馆，以查找随机对照试验（RCT）。本研究主要评估小檗属植物对改善血糖指标的影响，次要指标包括肥胖、血压和血脂参数。
在回顾了784篇文章后，我们纳入了8项RCT的数据，涉及451名T2DM患者。荟萃分析结果表明，服用小檗属植物可显著降低体重（加权均数差：-2.25；95%置信区间：-3.11至-1.39）、体重指数（BMI，加权均数差：-0.57；95%置信区间：-0.98至-0.17）、甘油三酯（加权均数差：-19.32；95%置信区间：-30.95至-1.69）、总胆固醇（加权均数差：-28.57；95%置信区间：-30.22至-21.51）、低密度脂蛋白胆固醇（加权均数差：-17.47；95%置信区间：-24.18至-10.75）、空腹血糖（加权均数差：-14.54；95%置信区间：-23.83，-5.25）、糖化血红蛋白（加权均数差：-0.65；95%置信区间：-1.30，-0.00）、胰岛素抵抗指数（加权均数差：-1.82；95%置信区间：-3.60，-0.05）和胰岛素（加权均数差：-4.40；95%置信区间：-7.15，-1.65）。然而，小檗属植物干预对血压和高密度脂蛋白胆固醇水平未观察到统计学显著影响。
本荟萃分析提示小檗属植物对T2DM可能有益。然而，需要更广泛的试验来明确证实其优势。
