小檗（普通小檗和全缘叶小檗）对2型糖尿病患者心血管危险因素的影响：一项系统评价、荟萃分析和GRADE评估

The Effect of Berberis (Vulgaris and Integerrima) on Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and GRADE Assessment.

作者信息

Musazadeh Vali, Hamidi Niloofar, Noormohammadi Morvarid, Shidfar Farzad

机构信息

Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Curr Ther Res Clin Exp. 2025 Mar 26;102:100788. doi: 10.1016/j.curtheres.2025.100788. eCollection 2025.

INTRODUCTION AND AIM

Type 2 diabetes mellitus (T2DM) raises cardiovascular disease risk, but evidence on Berberis's impact is limited and inconsistent. This systematic review and meta-analysis aimed to assess effect of Berberis supplement on cardiovascular risk factors in patients with T2DM.

MATERIALS AND METHODS

We extensively searched Embase, Web of Science, Scopus, PubMed, and the Cochrane Library for randomized controlled trials (RCTs) up to October 25, 2024. This study primarily assesses Berberis's impact on improving glycemic indices, with secondary measures including obesity, blood pressure and lipid profile parameters.

FINDINGS

After reviewing 784 articles, we included data from eight RCTs involving 451 participants with T2DM. The results of meta-analysis indicated that Berberis administration significantly reduced weight (WMD: -2.25; 95% CI: -3.11 to -1.39), body mass index (BMI, WMD: -0.57; 95% CI: -0.98 to -0.17), TG (WMD: -19.32; 95% CI: -30.95 to -1.69), TC (WMD: -28.57; 95% CI: -30.22 to -21.51), LDL-C (WMD: -17.47; 95% CI: -24.18 to -10.75), FBS (WMD: -14.54; 95% CI: -23.83, -5.25), HbA1c (WMD: -0.65; 95% CI: -1.30, -0.00), HOMA-IR (WMD: -1.82; 95% CI: -3.60, -0.05), and insulin (WMD: -4.40; 95% CI: -7.15, -1.65). However, no statistically significant effect on blood pressure and HDL-C level was observed with Berberis intervention.

CONCLUSION

This meta-analysis hints at Berberis's potential benefits for T2DM. However, more extensive trials are needed to confirm its advantages definitively.

引言与目的

2型糖尿病（T2DM）会增加心血管疾病风险，但关于小檗属植物影响的证据有限且不一致。本系统评价和荟萃分析旨在评估小檗属植物补充剂对T2DM患者心血管危险因素的影响。

材料与方法

我们广泛检索了截至2024年10月25日的Embase、科学网、Scopus、PubMed和Cochrane图书馆，以查找随机对照试验（RCT）。本研究主要评估小檗属植物对改善血糖指标的影响，次要指标包括肥胖、血压和血脂参数。

研究结果

在回顾了784篇文章后，我们纳入了8项RCT的数据，涉及451名T2DM患者。荟萃分析结果表明，服用小檗属植物可显著降低体重（加权均数差：-2.25；95%置信区间：-3.11至-1.39）、体重指数（BMI，加权均数差：-0.57；95%置信区间：-0.98至-0.17）、甘油三酯（加权均数差：-19.32；95%置信区间：-30.95至-1.69）、总胆固醇（加权均数差：-28.57；95%置信区间：-30.22至-21.51）、低密度脂蛋白胆固醇（加权均数差：-17.47；95%置信区间：-24.18至-10.75）、空腹血糖（加权均数差：-14.54；95%置信区间：-23.83，-5.25）、糖化血红蛋白（加权均数差：-0.65；95%置信区间：-1.30，-0.00）、胰岛素抵抗指数（加权均数差：-1.82；95%置信区间：-3.60，-0.05）和胰岛素（加权均数差：-4.40；95%置信区间：-7.15，-1.65）。然而，小檗属植物干预对血压和高密度脂蛋白胆固醇水平未观察到统计学显著影响。