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碳纳米颗粒 - 亚铁（II）配合物对三阴性乳腺癌的光热治疗效果及生物安全性

Photothermal therapeutic effects and biosafety of a carbon nanoparticles-Fe(ii) complex for triple-negative breast cancer.

作者信息

Huang Yuanfang, Tang Kexin, Zeng Guangfu, Yuan Huahui, Xin Qian, Zhao Yufeng, Qu Ting, Yang Jinmei, Zeng Cheng, Wu Xian, Gou Zehui, Xie Ping, Yang Sheng-Tao, Tang Xiaohai

机构信息

Sichuan Enray Pharmaceutical Sciences Company Chengdu 610041 China

School of Chemistry and Environment, Southwest Minzu University Chengdu 610041 China

出版信息

RSC Adv. 2025 Jun 10;15(25):19665-19675. doi: 10.1039/d5ra03041b.

DOI:10.1039/d5ra03041b
PMID:40503306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12150394/
Abstract

Triple-negative breast cancer (TNBC) has become a major challenge in clinical treatment due to its highly aggressive nature and limited therapeutic options. A carbon nanoparticles-Fe(ii) complex (CNSI-Fe), as both a ferroptosis inducer and photothermal agent (PTA), could exert anticancer effects through the ferroptosis pathway and photothermal action. Herein, we evaluated the photothermal therapeutic effects of CNSI-Fe in mice bearing the model tumor of TNBC (4T1 tumor). The therapeutic effects of CNSI-Fe were compared without/with near-infrared (NIR) irradiation both and . The therapeutic mechanisms and biosafety were also investigated. CNSI-Fe exhibits excellent photothermal conversion efficiency. CNSI-Fe had significant cytotoxicity against TNBC cells, and photothermal therapy (PTT) further enhanced its antitumor effects. The combination of CNSI-Fe and PTT treatments exhibited a more pronounced tumor-suppressive effect and longer survival time comparing to single modality treatment. Mechanistic studies indicated that PTT facilitated the entry of iron ions from CNSI-Fe into cancer cells, generating more hydroxyl radicals and significantly enhancing the ferroptosis. The haematological and serum biological parameters associated with the histopathological observations indicated that the side-effects of CNSI-Fe were low during PTT. Overall, we evidenced the synergistic effect of CNSI-Fe chemotherapy and PTT for TNBC treatment with low toxicity.

摘要

三阴性乳腺癌（TNBC）因其高度侵袭性和有限的治疗选择，已成为临床治疗中的一大挑战。碳纳米颗粒 - 铁（II）配合物（CNSI - Fe）作为一种铁死亡诱导剂和光热剂（PTA），可通过铁死亡途径和光热作用发挥抗癌作用。在此，我们评估了CNSI - Fe对携带TNBC模型肿瘤（4T1肿瘤）小鼠的光热治疗效果。比较了有无近红外（NIR）照射时CNSI - Fe的治疗效果。同时还研究了其治疗机制和生物安全性。CNSI - Fe表现出优异的光热转换效率。CNSI - Fe对TNBC细胞具有显著的细胞毒性，光热疗法（PTT）进一步增强了其抗肿瘤作用。与单一治疗方式相比，CNSI - Fe与PTT联合治疗表现出更显著的肿瘤抑制作用和更长的生存时间。机制研究表明，PTT促进了CNSI - Fe中的铁离子进入癌细胞，产生更多羟基自由基并显著增强铁死亡。与组织病理学观察相关的血液学和血清生物学参数表明，PTT期间CNSI - Fe的副作用较低。总体而言，我们证明了CNSI - Fe化疗与PTT联合治疗TNBC具有低毒性的协同效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/ef81a4ac2812/d5ra03041b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/2f7602b9da5d/d5ra03041b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/2678648eff58/d5ra03041b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/6ec9574d0461/d5ra03041b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/43ee46eda0fe/d5ra03041b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/6afd7de86391/d5ra03041b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/ef81a4ac2812/d5ra03041b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/2f7602b9da5d/d5ra03041b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/2678648eff58/d5ra03041b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/6ec9574d0461/d5ra03041b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/43ee46eda0fe/d5ra03041b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/6afd7de86391/d5ra03041b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/12150394/ef81a4ac2812/d5ra03041b-f6.jpg

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引用本文的文献

[1]
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer.

Cell Biol Toxicol. 2025-7-22

本文引用的文献

[1]
Carbon nanoparticles-Fe(II) complex combined with sorafenib for ferroptosis-induced antitumor effects in triple-negative breast cancer.

Colloids Surf B Biointerfaces. 2025-6

[2]
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.

Adv Sci (Weinh). 2025-4

[3]
A PTT-Induced Feed-Back Carbon Nanosystem for Enhanced Breast Cancer Therapy by Extracellular Matrix Remodeling.

Nano Lett. 2025-2-26

[4]
High Carbonyl Graphene Oxide Suppresses Colorectal Cancer Cell Proliferation and Migration by Inducing Ferroptosis via the System Xc-/GSH/GPX4 Axis.

Pharmaceutics. 2024-12-17

[5]
A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade.

Mater Today Bio. 2024-11-16

[6]
Biotinylated platinum(IV)-conjugated graphene oxide nanoparticles for targeted chemo-photothermal combination therapy in breast cancer.

Biomater Adv. 2025-3

[7]
FeS@COF based nanocarrier for photothermal-enhanced chemodynamic/thermodynamic tumor therapy and immunotherapy via reprograming tumor-associated macrophages.

J Nanobiotechnology. 2024-11-15

[8]
Near-Infrared Driven Gold Nanoparticles-Decorated g-CN/SnS Heterostructure through Photodynamic and Photothermal Therapy for Cancer Treatment.

Int J Nanomedicine. 2024

[9]
Photothermal FeO nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy.

J Nanobiotechnology. 2024-10-16

[10]
Autophagy Blockage Enhancing Photothermal and Chemodynamic Synergistic Therapy Based on HCQ/CuS Nanoplatform.

Adv Healthc Mater. 2024-12

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