Orlandi Riccardo
Department of Thoracic Surgery, University of Milan, Milan 20122, Italy.
World J Clin Oncol. 2025 May 24;16(5):106630. doi: 10.5306/wjco.v16.i5.106630.
Neuroendocrine neoplasms are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, most frequently in the gastrointestinal tract and in the lung. The latest 2021 World Health Organization (WHO) classification of lung tumors defines neuroendocrine neoplasms of the lung as an independent group of tumors, including typical and atypical neuroendocrine tumors and small cell and large cell neuroendocrine carcinomas. Although the overall nomenclature is essentially unchanged from the fourth WHO classification, there are several clinically relevant updates. In this review article, we discuss the epidemiological, clinical, diagnostic, therapeutic and prognostic features of these fascinating neoplasms, including the latest insights, current challenges and future perspectives.
神经内分泌肿瘤是一组恶性程度各异的肿瘤，起源于神经内分泌细胞，最常见于胃肠道和肺部。2021年世界卫生组织（WHO）最新的肺肿瘤分类将肺神经内分泌肿瘤定义为一组独立的肿瘤，包括典型和非典型神经内分泌肿瘤以及小细胞和大细胞神经内分泌癌。尽管总体命名与WHO第四版分类基本一致，但有一些与临床相关的更新。在这篇综述文章中，我们讨论了这些引人入胜的肿瘤的流行病学、临床、诊断、治疗和预后特征，包括最新见解、当前挑战和未来展望。
