肺部神经内分泌肿瘤的小活检和细胞学：分类、免疫组织化学、分子谱和世界卫生组织更新的简要概述。
Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates.
机构信息
Department of Pathology & Cell Biology, Columbia University Irving Medical Center.
Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital-Weill Cornell Medical College.
出版信息
Adv Anat Pathol. 2022 Nov 1;29(6):329-336. doi: 10.1097/PAP.0000000000000360. Epub 2022 Sep 2.
Pulmonary neuroendocrine neoplasms comprise ~20% of all lung tumors. Typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma represent the 4 major distinct subtypes recognized on resections. This review provides a brief overview of the cytomorphologic features and the 2021 World Health Organization classification of these tumor types on small biopsy and cytology specimens. Also discussed are the role of immunohistochemistry in the diagnosis and molecular signatures of pulmonary neuroendocrine tumors.
肺神经内分泌肿瘤约占所有肺部肿瘤的 20%。在切除标本中，典型类癌、非典型类癌、小细胞癌和大细胞神经内分泌癌代表了 4 种主要的不同亚型。本文简要概述了小活检和细胞学标本中这些肿瘤类型的细胞形态特征和 2021 年世界卫生组织分类，还讨论了免疫组织化学在肺神经内分泌肿瘤诊断中的作用和分子特征。
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