Krugliak Netanel, Silverberg Mark S
Mount Sinai Hospital Inflammatory Bowel Disease Center, Toronto, ON, Canada.
Division of Gastroenterology, Department of Medicine, Mount Sinai Hospital Inflammatory Bowel Disease Center, Toronto, ON, Canada.
Case Rep Gastroenterol. 2025 Jun 11;19(1):423-427. doi: 10.1159/000546012. eCollection 2025 Jan-Dec.
Curcumin and QingDai (QD, indigo) are two herbal extracts used in traditional medicine. A combination of curcumin with QD (CurQD) was reported to be effective in ulcerative colitis, but its effectiveness in Crohn's disease (CD) is unknown. We report on the use of CurQD for the treatment of CD.
The patient was a 35-year-old male with colonic and perianal CD responsive to infliximab therapy, who had to discontinue therapy due to a concomitant cardiomyopathy diagnosis. After cessation of infliximab treatment, he experienced clinical and endoscopic relapse which responded to initiation of CurQD therapy with regained clinical and endoscopic remission.
In summary, the present case report describes, for the first time, a possible benefit of CurQD nutraceutical in the induction and maintenance of remission in a Crohn's patient. However, more data, preferably from adequately powered randomized controlled trials, are needed to corroborate these observations.
姜黄素和青黛是传统医学中使用的两种草药提取物。据报道，姜黄素与青黛的组合（CurQD）对溃疡性结肠炎有效，但其对克罗恩病（CD）的有效性尚不清楚。我们报告了CurQD用于治疗CD的情况。
该患者为一名35岁男性，患有结肠和肛周CD，对英夫利昔单抗治疗有反应，但因同时诊断为心肌病而不得不停止治疗。英夫利昔单抗治疗停止后，他经历了临床和内镜复发，CurQD治疗开始后临床和内镜缓解，病情得到改善。
总之，本病例报告首次描述了CurQD营养保健品在一名克罗恩病患者诱导和维持缓解方面可能具有的益处。然而，需要更多数据，最好是来自充分有力的随机对照试验的数据，来证实这些观察结果。
