Pagani G, Rezzonico R, Marini A
Acta Paediatr Scand. 1985 Sep;74(5):681-6. doi: 10.1111/j.1651-2227.1985.tb10013.x.
Nine preterm newborn infants were maintained on conventional mechanical ventilation for respiratory diseases were given high frequency jet ventilation in the same inspired FiO2 for short periods (10-120 min). Lower mean airway pressures were used in high frequency jet ventilation (0.70 +/- 0.2 kPa versus 0.96 +/- 0.2 kPa in intermittent positive pressure ventilation), and peak inspiratory pressures were reduced from 2.06 +/- 0.4 to 1.38 +/- 0.24 kPa. Respiratory and haemodynamic data were compared with those obtained in intermittent positive pressure ventilation, PaO2 and PCO2 were similar, while an increase in pH and reduction of central venous pressure were observed during high frequency jet ventilation. This preliminary study indicates that high frequency jet ventilation provides good ventilatory support, at least for short periods, with reduced airway pressures, and could be a promising technique for prevention of acute and chronic pulmonary barotrauma.
9例因呼吸系统疾病接受传统机械通气的早产新生儿，在相同吸入氧浓度下接受了短时间（10 - 120分钟）的高频喷射通气。高频喷射通气时使用的平均气道压力较低（0.70±0.2 kPa，而间歇正压通气时为0.96±0.2 kPa），吸气峰压从2.06±0.4降至1.38±0.24 kPa。将呼吸和血流动力学数据与间歇正压通气时获得的数据进行比较，动脉血氧分压（PaO2）和二氧化碳分压（PCO2）相似，而在高频喷射通气期间观察到pH值升高和中心静脉压降低。这项初步研究表明，高频喷射通气至少在短时间内可提供良好的通气支持，同时降低气道压力，可能是预防急慢性肺气压伤的一种有前景的技术。
