Donn S M, Nicks J J, Bandy K P, Naglie R A
Pediatr Pulmonol. 1985 Sep-Oct;1(5):267-71. doi: 10.1002/ppul.1950010509.
During a 14-month period 11 preterm infants were treated with high-frequency jet ventilation for severe respiratory failure that had been unresponsive to conventional mechanical ventilation. Primary indications included intractable air leaks (pulmonary interstitial emphysema, pneumothorax, or both), congenital diaphragmatic hernia, and progressive pneumonia. The Sechrist 990 HFV respirator, a solenoid-driven, pulse-generated high frequency jet ventilator, was used. This device delivers a volume of gas at a controlled pressure to a jet located in the patient connector proximal to a standard single lumen endotracheal tube. The ventilator was operated in tandem with a Sechrist IV-100B ventilator to provide a sigh effect and to improve humidification. Although only 3 of 11 patients survived, 9 displayed short-term benefits from HFJV with significant reduction in mean airway pressure and improvement in mean arterial blood pressure, and no concomitant adverse effects on oxygenation or ventilation. Preliminary results suggest short-term benefits of HFJV in infants who have severe respiratory failure that is unresponsive to conventional mechanical ventilation.
在14个月的时间里，11名早产婴儿因对传统机械通气无反应的严重呼吸衰竭而接受了高频喷射通气治疗。主要指征包括难治性气漏（肺间质肺气肿、气胸或两者兼有）、先天性膈疝和进行性肺炎。使用的是Sechrist 990高频通气呼吸器，这是一种由电磁阀驱动、脉冲产生的高频喷射通气机。该设备以受控压力将一定体积的气体输送到位于靠近标准单腔气管内导管的患者连接器中的喷射口。该通气机与Sechrist IV - 100B通气机串联操作，以提供叹息效应并改善湿化。虽然11名患者中只有3名存活，但9名患者显示出高频喷射通气的短期益处，平均气道压力显著降低，平均动脉血压改善，且对氧合或通气无伴随的不良影响。初步结果表明，高频喷射通气对传统机械通气无反应的严重呼吸衰竭婴儿有短期益处。
