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大鼠缺血后早期肾脏纤维蛋白沉积及肾小球滤过率降低：去纤维蛋白剂阿尔文的作用

Early postischaemic renal fibrin deposition and reduction of glomerular filtration rate in the rat: effect of the defibrinating agent Arwin.

作者信息

Losonczy G

出版信息

Acta Physiol Hung. 1985;66(2):183-7.

PMID:4050462
Abstract

The correlation between the extent of intrarenal fibrin deposition induced by 15, 20 and 30-min bilateral occlusion of the renal arteries and the reduction of glomerular filtration rate (GFR) has been studied. The tissue level of fibrin was estimated by 125I-labelled human fibrinogen. There was a significant negative correlation between cortical and medullary fibrin content and GFR. In rats pretreatment with the defibrinating agent Arwin failed to prevent postischaemic coagulation in the kidney and the reduction of GFR.

摘要

研究了肾动脉双侧阻断15、20和30分钟所诱导的肾内纤维蛋白沉积程度与肾小球滤过率（GFR）降低之间的相关性。通过125I标记的人纤维蛋白原来估计纤维蛋白的组织水平。皮质和髓质纤维蛋白含量与GFR之间存在显著的负相关。在用去纤维蛋白剂Arwin预处理的大鼠中，未能预防肾脏缺血后凝血和GFR的降低。

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