Olsson K, Dahlborn K
Acta Physiol Scand. 1985 Aug;124(4):597-601. doi: 10.1111/j.1748-1716.1985.tb00053.x.
The effects of the long-acting synthetic vasopressin analogue desmopressin (dose 2 X 2 micrograms day-1 for two days) were investigated in pregnant, lactating and anoestral goats. Urine flow fell and urine osmolality increased in all experiments. However, pregnant goats continued to drink the same volumes of water each day with the result that the ratio of water intake/urine output increased markedly and the plasma osmolality fell. The results support the hypothesis that the regulation of water intake is changed during pregnancy and that pregnant goats have a lowered sensitivity to signals that normally inhibit water consumption. In lactating goats, milk secretion was not affected by desmopressin. The animals did not drink enough to compensate for the water losses in milk and urine, but more than was needed to cover the water losses in the urine. The plasma osmolality decreased slightly. It appears as if the mechanisms involved in the control of water balance are not sufficiently adapted to take water losses via the milk into account, if the animals are subjected to challenges. In anoestral animals, the water balance was maintained during desmopressin injections. The renal sodium excretion did not change, but the renal potassium excretion decreased in pregnant and lactating goats in response to desmopressin.
在怀孕、泌乳和处于乏情期的山羊身上研究了长效合成血管加压素类似物去氨加压素（剂量为2×2微克/天，持续两天）的作用。在所有实验中，尿流量下降，尿渗透压升高。然而，怀孕山羊每天的饮水量保持不变，结果水摄入量/尿量的比值显著增加，血浆渗透压下降。这些结果支持了以下假设：怀孕期间水摄入量的调节发生了变化，怀孕山羊对通常抑制饮水的信号敏感性降低。在泌乳山羊中，去氨加压素对乳汁分泌没有影响。动物饮水不足以补偿乳汁和尿液中的水分流失，但比仅补偿尿液中的水分流失所需的饮水量要多。血浆渗透压略有下降。如果动物受到刺激，似乎参与水平衡控制的机制没有充分适应考虑通过乳汁造成的水分流失。在乏情期动物中，注射去氨加压素期间水平衡得以维持。肾钠排泄没有变化，但怀孕和泌乳山羊的肾钾排泄因去氨加压素而减少。
