Suenson M
Acta Physiol Scand. 1985 Sep;125(1):81-90. doi: 10.1111/j.1748-1716.1985.tb07694.x.
The source-load interaction during impulse propagation of excited and unexcited cells respectively was studied in the working myocardium. Velocity of propagation and the shape of the early part of the action potential was measured in ferret papillary muscles or trabeculae with the preparation surrounded by either a large volume or a thin layer of Tyrode solution, the latter situation being established by means of a silicone fluid bath technique. Quick changes between the two situations resulted in changes in the time constant of the foot of the action potential and maximal rate of depolarization of the action potential and in changes in excitation lag of the more deeply placed cells with respect to the surface cells. These results could be explained by the effect of changes in the shape of the wavefront of excitation. With a large Tyrode volume around the preparation, corresponding to physiological conditions, the curved configuration of the wavefront of excitation was so pronounced that one-dimensional cable theory was highly inadequate to describe the conditions for propagation.
分别在工作心肌中研究了兴奋和未兴奋细胞冲动传播过程中的源-负载相互作用。在雪貂乳头肌或小梁中测量传播速度和动作电位早期部分的形状，标本周围环绕着大量或薄层的台氏液，后一种情况通过硅油浴技术实现。两种情况之间的快速变化导致动作电位足部时间常数、动作电位最大去极化速率的变化，以及更深层细胞相对于表面细胞的兴奋延迟的变化。这些结果可以用兴奋波前形状的变化效应来解释。在标本周围有大量台氏液的情况下，对应于生理条件，兴奋波前的弯曲形态非常明显，以至于一维电缆理论极不足以描述传播条件。
